February 2015

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS.

Nat Commun. 2015 Feb 18;6:6217. doi: 10.1038/ncomms7217.

[PubMed - as supplied by publisher]


Wang N, Rayes RF, Elahi SM, Lu Y, Hancock MA, Massie B, Rowe GE, Aomari H, Hossain S, Durocher Y, Pinard M, Tabariès S, Siegel PM, Brodt P.

Mol Cancer Ther. 2015 Feb 11. pii: molcanther.0751.2014. [Epub ahead of print]

PMID: 25673819  [PubMed - as supplied by publisher]


Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells.

Arabzadeh A, Dupaul-Chicoine J, Breton V, Haftchenary S, Yumeen S, Turbide C, Saleh M, McGregor K, Greenwood CM, Akavia UD, Blumberg RS, Gunning PT, Beauchemin N.

Gut. 2015 Feb 9. pii: gutjnl-2014-308781. doi: 10.1136/gutjnl-2014-308781. [Epub ahead of print]

PMID: 25666195  [PubMed - as supplied by publisher]


SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lungcancer.

Papadakis AI, Sun C, Knijnenburg TA, Xue Y, Grernrum W, Hölzel M, Nijkamp W, Wessels LF, Beijersbergen RL, Bernards R, Huang S.

Cell Res. 2015 Feb 6. doi: 10.1038/cr.2015.16. [Epub ahead of print]




Analysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.

Sriskandarajah N, Blanchette P, Kucharski TJ, Teodoro J, Branton PE.

J Virol. 2015 Feb 4. pii: JVI.03437-14. [Epub ahead of print]






Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion and metastasis.

Pettersson F, Del Rincon SV, Emond A, Huor B, Ngan E, Ng J, Dobocan MC, Siegel PM, Miller WH Jr.

Cancer Res. 2015 Jan 21. pii: canres.1996.2014. [Epub ahead of print]

PMID:25608710  [PubMed - as supplied by publisher]


The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo.

Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJ, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG.

Immunity. 2015 Jan 20;42(1):41-54. doi: 10.1016/j.immuni.2014.12.030. Epub 2015 Jan 2.


mTOR coordinates protein synthesis, mitochondrial activity and proliferation.

Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, Topisirovic I.

Cell Cycle. 2015 Jan 15:0. [Epub ahead of print]

  January 2015

The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.

Ramdzan ZM, Pal R, Kaur S, Leduy L, Bérubé G, Davoudi S, Vadnais C, Nepveu A.

Oncotarget. 2015 Jan 8. [Epub ahead of print]

[PubMed - as supplied by publisher] 
Free Article


Developmental differences in the expression of FGF receptors between human and mouse embryos.

Kunath T, Yamanaka Y, Detmar J, MacPhee D, Caniggia I, Rossant J, Jurisicova A.

Placenta. 2014 Dec;35(12):1079-88. doi: 10.1016/j.placenta.2014.09.008. Epub 2014 Sep 23.

[PubMed - in process]

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

Bah A, Vernon RM, Siddiqui Z, Krzeminski M, Muhandiram R, Zhao C, Sonenberg N, Kay LE, Forman-Kay JD.

Nature. 2014 Dec 22. doi: 10.1038/nature13999. [Epub ahead of print]

  December 2014   

Absolute assignment of breast cancer intrinsic molecular subtype.

Paquet ER, Hallett MT.

J Natl Cancer Inst. 2014 Dec 4;107(1):357. doi: 10.1093/jnci/dju357. Print 2015 Jan.


Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.

Foveau B, Van Der Kraak L, Beauchemin N, Albrecht S, LeBlanc AC.

PLoS One. 2014 Dec 3;9(12):e114270. doi: 10.1371/journal.pone.0114270. eCollection 2014.

[PubMed - in process] 
Free PMC Article

Chemoprevention Activity of 25-Hydroxyvitamin D in the MMTV-PyMT Mouse Model of BreastCancer.

Rossdeutscher L, Li J, Luco AL, Fadhil I, Ochietti B, Camirand A, Huang DC, Reinhardt TA, Muller W, Kremer R.

Cancer Prev Res (Phila). 2015 Feb;8(2):120-8. doi: 10.1158/1940-6207.CAPR-14-0110. Epub 2014 Dec 2.



     November 2014 Phase I/II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Patients With Locally Advanced or Metastatic Breast Cancer.

Bendell J, Saleh M, Rose AA, Siegel PM, Hart L, Sirpal S, Jones S, Green J, Crowley E, Simantov R, Keler T, Davis T, Vahdat L.

J Clin Oncol. 2014 Nov 10;32(32):3619-25. doi: 10.1200/JCO.2013.52.5683. Epub 2014 Sep 29.


Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice.
El-Assaad W, El-Kouhen K, Mohammad AH, Yang J, Morita M, Gamache I, Mamer O, Avizonis D, Hermance N, Kersten S, Tremblay ML, Kelliher MA, Teodoro JG.
Diabetologia. 2014 Nov 9. [Epub ahead of print]

Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.

Liu X, Giguère V.

Nucl Recept Signal. 2014 Nov 4;12:e004. doi: 10.1621/nrs.12004. eCollection 2014.

[PubMed - in process] 
Free PMC Article

      Estrogen-Related Receptor Alpha coordinates transcriptional programs essential for exercise tolerance and muscle fitness.

Perry MC, Dufour CR, Tam IS, B'chir W, Giguère V.

Mol Endocrinol. 2014 Oct 31:me20141281. [Epub ahead of print]

      CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2014 Oct 26. doi: 10.1038/nature13848.

     October 2014 MS/MS-based strategies for proteomic profiling of invasive cell structures.

Havrylov S, Park M.

Proteomics. 2014 Oct 10. doi: 10.1002/pmic.201400220. [Epub ahead of print]

  The prognostic ease and difficulty of invasive breast carcinoma.

Tofigh A, Suderman M, Paquet ER, Livingstone J, Bertos N, Saleh SM, Zhao H, Souleimanova M, Cory S, Lesurf R, Shahalizadeh S, Garcia Lopez N, Riazalhosseini Y, Omeroglu A, Ursini-Siegel J, Park M., Dumeaux V, Hallett M.

Cell Rep. 2014 Oct 9;9(1):129-42. doi: 10.1016/j.celrep.2014.08.073. Epub 2014 Oct 2.

[PubMed - in process] 
Free Article

MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.

Fukao A, Mishima Y, Takizawa N, Oka S, Imataka H, Pelletier J, Sonenberg N, Thoma C, Fujiwara T.

Mol Cell. 2014 Oct 2;56(1):79-89. doi: 10.1016/j.molcel.2014.09.005.

[PubMed - in process]




The ever-evolving role of mTOR in translation.

Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A.

Semin Cell Dev Biol. 2014 Sep 26. pii: S1084-9521(14)00269-9. doi: 10.1016/j.semcdb.2014.09.014. [Epub ahead of print] Review.

PMID: 25263010

          September 2014             

ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.

Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V.

Mol Cell Biol. 2014 Sep 22. pii: MCB.00895-14. [Epub ahead of print]



Differential effects of AMPK agonists on cell growth and metabolism.


Vincent EE, Coelho PP, Blagih J, Griss T, Viollet B, Jones RG.

Oncogene. 2014 Sep 22. doi: 10.1038/onc.2014.301. [Epub ahead of print]






Coordinated cell behaviours in early urogenital system morphogenesis.


Stewart K, Bouchard M.

Semin Cell Dev Biol. 2014 Sep 16. pii: S1084-9521(14)00256-0. doi: 10.1016/j.semcdb.2014.09.001. [Epub ahead of print] Review.






Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers.


Vadnais C, Shooshtarizadeh P, Rajadurai CV, Lesurf R, Hulea L, Davoudi S, Cadieux C, Hallett M, Park M, Nepveu A.

Biol Open. 2014 Sep 12. pii: BIO20148193. doi: 10.1242/bio.20148193. [Epub ahead of print]






Distinctive tRNA Repertoires in Proliferating versus Differentiating Cells.


Topisirovic I, Sonenberg N.

Cell. 2014 Sep 11;158(6):1238-9. doi: 10.1016/j.cell.2014.08.031.






Interaction of Adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.

Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG.

J Virol. 2014 Sep 10. pii: JVI.00933-14. [Epub ahead of print]






A regulatory network controls nephrocan expression and midgut patterning.

Hou J, Wei W, Saund RS, Xiang P, Cunningham TJ, Yi Y, Alder O, Lu DY, Savory JG, Krentz NA, Montpetit R, Cullum R, Hofs N, Lohnes D, Humphries RK, Yamanaka Y, Duester G, Saijoh Y, Hoodless PA.

Development. 2014 Sep 10. pii: dev.108274. [Epub ahead of print]






CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.

Ramdzan ZM, Nepveu A.

Nat Rev Cancer. 2014 Sep 5. doi: 10.1038/nrc3805. [Epub ahead of print]






DICER1: mutations, microRNAs and mechanisms.

Foulkes WD, Priest JR, Duchaine TF.

Nat Rev Cancer. 2014 Sep 1. doi: 10.1038/nrc3802. [Epub ahead of print]






  August 2014            

Metformin directly acts on mitochondria to alter cellular bioenergetics.

Andrzejewski S, Gravel SP, Pollak M, St-Pierre J.

Cancer Metab. 2014 Aug 28;2:12. doi: 10.1186/2049-3002-2-12. eCollection 2014.

PMID: 25184038



Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancercells is mediated by PARP activation and enhanced NAD consumption.

Chan M, Gravel M, Bramoulle A, Bridon G, Avizonis D, Shore GC, Roulston A.

Cancer Res. 2014 Aug 21. pii: canres.0809.2014. [Epub ahead of print]

PMID: 25145669


Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.

Bagci H, Laurin M, Huber J, Muller WJ, Côté JF.

Cell Death Dis. 2014 Aug 14;5:e1375. doi: 10.1038/cddis.2014.338.

        Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3.

Archibald A, Mihai C, Macara IG, McCaffrey L.

Oncogene. 2014 Aug 11;0. doi: 10.1038/onc.2014.242. [Epub ahead of print]

   July 2014      

Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo.

Anani S, Bhat S, Honma-Yamanaka N, Krawchuk D, Yamanaka Y.

Development. 2014 Jul;141(14):2813-24. doi: 10.1242/dev.107276. Epub 2014 Jun 19.


Circulation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts.

Tanaka Y, Sanchez V, Takata N, Yokomizo T, Yamanaka Y, Kataoka H, Hoppe PS, Schroeder T, Nishikawa S.

Cell Rep. 2014 Jul 10;8(1):31-9. doi: 10.1016/j.celrep.2014.05.055. Epub 2014 Jun 26.

[PubMed - in process]

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.

Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N.

RNA. 2014 Jul 17. [Epub ahead of print]

[PubMed - as supplied by publisher]

APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly.

Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG.

Cell. 2014 Jul 17;158(2):368-82. doi: 10.1016/j.cell.2014.05.042.

        p66ShcA Promotes Breast Cancer Plasticity by Inducing an Epithelial to Mesenchymal Transition.

Hudson J, Ha JR, Sabourin V, Ahn R, La Selva R, Livingstone J, Podmore L, Knight J, Forrest L, Beauchemin N, Hallett M, Park M, Ursini-Siegel J.

Mol Cell Biol. 2014 Jul 28. pii: MCB.00341-14. [Epub ahead of print]

  June 2014        

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

Ming Yan, Marie-Claude Gingras, Elaine A. Dunlop, Yann Nouët, Fanny Dupuy, Zahra Jalali, Elite Possik, Barry J. Coull, Dmitri Kharitidi, Anders Bondo Dydensborg, Brandon Faubert, Miriam Kamps, Sylvie Sabourin, Rachael S. Preston, David Mark Davies, Taren Roughead, Laëtitia Chotard, Maurice A.M. van Steensel, Russell Jones, Andrew R. Tee, Arnim Pause

J Clin Invest. 2014 June 2; 124(6): 2640–2650. Published online 2014 April 24. doi: 10.1172/JCI71749

PMCID: PMC4038567


Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.

Robichaud N, Del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N.

Oncogene. 2014 Jun 9. doi: 10.1038/onc.2014.146. [Epub ahead of print]



Translational control of immune responses: from transcripts to translatomes.


Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N, Larsson O.

Nat Immunol. 2014 Jun;15(6):503-11. doi: 10.1038/ni.2891. Review.




  May 2014         

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.

Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J.

Oncogene. 2014 May 19. doi: 10.1038/onc.2014.110. [Epub ahead of print]



Amino acids fuel T cell-mediated inflammation.


Poffenberger MC, Jones RG.

Immunity. 2014 May 15;40(5):635-7. doi: 10.1016/j.immuni.2014.04.017.






YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway.


Zhao Y, Khanal P, Savage P, She YM, Cyr TD, Yang X.

Cancer Res. 2014 May 8. [Epub ahead of print]





Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.

Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset PO, Bechet D, Faury D, De Jay N, Ramkissoon LA, Corcoran A, Jones DT, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers DC, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Leary S, Jallo G, Cohen K, Gupta N, Prados MD, Carret AS, Ellezam B, Crevier L, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Dong Z, Siegel PM, Malkin H, Ligon AH, Albrecht S, Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW.

Nat Genet. 2014 May;46(5):462-6. doi: 10.1038/ng.2950. Epub 2014 Apr 6.

  April 2014       

Stable isotope tracer analysis in isolated mitochondria from Mammalian systems.

Gravel SP, Andrzejewski S, Avizonis D, St-Pierre J.

Metabolites. 2014 Apr 10;4(2):166-83. doi: 10.3390/metabo4020166.



Gene regulatory network of renal primordium development.


Marcotte M, Sharma R, Bouchard M.

Pediatr Nephrol. 2014 Apr;29(4):637-44. doi: 10.1007/s00467-013-2635-0. Epub 2013 Oct 9.




  March 2014      

It takes two to tango in the microenvironment! Ursini-Siegel J, Park M. Breast Cancer Res. 2013 Mar 12;15(2):102. [Epub ahead of print] PMID: 23510134 [PubMed - as supplied by publisher]


Gata3 antagonizes cancer progression in Pten-deficient prostates. Nguyen AH, Tremblay M, Haigh K, Koumakpayi IH, Paquet M, Pandolfi PP, Mes-Masson AM, Saad F, Haigh JJ, Bouchard M. Hum Mol Genet. 2013 Mar 6. [Epub ahead of print] PMID: 23428429 [PubMed - as supplied by publisher]


Remote control of gene function by local translation.

Jung H, Gkogkas CG, Sonenberg N, Holt CE.

Cell. 2014 Mar 27;157(1):26-40. doi: 10.1016/j.cell.2014.03.005. Review.


Rewiring cell polarity signaling in cancer.

Halaoui R, McCaffrey L.

Oncogene. 2014 Mar 17. doi: 10.1038/onc.2014.59. [Epub ahead of print]



The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.


Hardy S, Uetani N, Wong N, Kostantin E, Labbé DP, Bégin LR, Mes-Masson A, Miranda-Saavedra D, Tremblay ML.

Oncogene. 2014 Mar 17. doi: 10.1038/onc.2014.33. [Epub ahead of print]





Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.

Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N.

Mol Cell Biol. 2014 Mar;34(6):1046-53. doi: 10.1128/MCB.01079-13. Epub 2014 Jan 6.

  February 2014      

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2554-9. doi: 10.1073/pnas.1312570111. Epub 2014 Feb 3.


Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.

Labbé DP, Nowak DG, Deblois G, Lessard L, Giguère V, Trotman LC, Tremblay ML.

Mol Cancer Res. 2014 Feb;12(2):184-9. doi: 10.1158/1541-7786.MCR-13-0477. Epub 2013 Dec 30.

  January 2014          

Translational control and autism-like behaviors.

Gkogkas CG, Sonenberg N.

Cell Logist. 2013 Jan 1;3(1):e24551. Epub 2013 Apr 4.


The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator.

Faubert B, Vincent EE, Poffenberger MC, Jones RG.

Cancer Lett. 2014 Jan 28. pii: S0304-3835(14)00054-8. doi: 10.1016/j.canlet.2014.01.018. [Epub ahead of print]



Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR.

Kleinman CL, Gerges N, Papillon-Cavanagh S, Sin-Chan P, Pramatarova A, Quang DA, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Fontebasso AM, Spence T, Schwartzentruber J, Albrecht S, Hauser P, Garami M, Klekner A, Bognar L, Montes JL, Staffa A, Montpetit A, Berube P, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel PM, Duchaine T, Perotti C, Fleming A, Faury D, Remke M, Gallo M, Dirks P, Taylor MD, Sladek R, Pastinen T, Chan JA, Huang A, Majewski J, Jabado N.

Nat Genet. 2014 Jan;46(1):39-44. doi: 10.1038/ng.2849. Epub 2013 Dec 8.

PMID: 24316981

Parallel measurement of dynamic changes in translation rates in single cells.

Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T.

Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10.


PMID: 24213167



Pseudophosphatases: methods of analysis and physiological functions.

Kharitidi D, Manteghi S, Pause A.

Methods. 2014 Jan 15;65(2):207-18. doi: 10.1016/j.ymeth.2013.09.009. Epub 2013 Sep 21.


PMID: 24064037 


  December 2013          

Arsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer.

Guilbert C, Annis MG, Dong Z, Siegel PM, Miller WH Jr, Mann KK.

PLoS One. 2013 Dec 31;8(12):e85995. doi: 10.1371/journal.pone.0085995. eCollection 2013.

[PubMed - in process]
         Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues.

Axford MM, Wang YH, Nakamori M, Zannis-Hadjopoulos M, Thornton CA, Pearson CE.

PLoS Genet. 2013 Dec;9(12):e1003866. doi: 10.1371/journal.pgen.1003866. Epub 2013 Dec 19.

         PGC-1α supports glutamine metabolism in breast cancer.

McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J.

Cancer Metab. 2013 Dec 5;1(1):22. doi: 10.1186/2049-3002-1-22.


FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst.

Krawchuk D, Honma-Yamanaka N, Anani S, Yamanaka Y.

Dev Biol. 2013 Dec 1;384(1):65-71. doi: 10.1016/j.ydbio.2013.09.023. Epub 2013 Sep 21.


Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis.

Beauchemin N, Arabzadeh A.

Cancer Metastasis Rev. 2013 Dec;32(3-4):643-71. doi: 10.1007/s10555-013-9444-6.


PMID: 23903773  


  November 2013      

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N.

Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001.

  October 2013       

Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.

Hong EJ, Levasseur MP, Dufour CR, Perry MC, Giguère V.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17975-80. doi: 10.1073/pnas.1315319110. Epub 2013 Oct 14.


A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis.

Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M.

Dev Biol. 2013 Oct 15;382(2):555-66. doi: 10.1016/j.ydbio.2013.07.028. Epub 2013 Aug 3.


PMID: 23920117 


  September 2013      

Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.

Ayoub E, Hall A, Scott AM, Chagnon MJ, Miquel G, Hallé M, Noda M, Bikfalvi A, Tremblay ML.

J Biol Chem. 2013 Sep 6;288(36):25739-48. doi: 10.1074/jbc.M113.501007. Epub 2013 Jul 29.




  August 2013       

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.

Dupuy F, Griss T, Blagih J, Bridon G, Avizonis D, Ling C, Dong Z, Siwak DR, Annis MG, Mills GB, Muller WJ, Siegel PM, Jones RG.

Cancer Metab. 2013 Aug 14;1(1):18. doi: 10.1186/2049-3002-1-18.


A truncated form of dicer tilts the balance of RNA interference pathways.

Sawh AN, Duchaine TF.

Cell Rep. 2013 Aug 15;4(3):454-63. doi: 10.1016/j.celrep.2013.07.013. Epub 2013 Aug 8.

PMID: 23933256  


 Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.

 Stewart K, Uetani N, Hendriks W, Tremblay ML, Bouchard M.

Development. 2013 Aug;140(16):3413-22. doi: 10.1242/dev.094532. Epub 2013 Jul 17.


PMID: 23863482




   July 2013        

Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer.

Maric G, Rose AA, Annis MG, Siegel PM.

Onco Targets Ther. 2013 Jul 9;6:839-52. doi: 10.2147/OTT.S44906. Print 2013.


Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer.

Maric G, Rose AA, Annis MG, Siegel PM.

Onco Targets Ther. 2013 Jul 9;6:839-52. doi: 10.2147/OTT.S44906. Print 2013.

        The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

Ahn R, Sabourin V, Ha JR, Cory S, Maric G, Im YK, Hardy WR, Zhao H, Park M, Hallett M, Siegel PM, Pawson T, Ursini-Siegel J.

Cancer Res. 2013 Jul 15;73(14):4521-32. doi: 10.1158/0008-5472.CAN-12-4178. Epub 2013 May 21.




   June 2013      

Gata3 antagonizes cancer progression in Pten-deficient prostates.

Nguyen AH, Tremblay M, Haigh K, Koumakpayi IH, Paquet M, Pandolfi PP, Mes-Masson AM, Saad F, Haigh JJ, Bouchard M.

Hum Mol Genet. 2013 Jun 15;22(12):2400-10. doi: 10.1093/hmg/ddt088. Epub 2013 Feb 20.


PMID: 23428429





   May 2013       

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N.

PLoS Biol. 2013;11(5):e1001564. doi: 10.1371/journal.pbio.1001564. Epub 2013 May 21.



A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.


Ngan E, Northey JJ, Brown CM, Ursini-Siegel J, Siegel PM.

J Cell Sci. 2013 May 1;126(Pt 9):1981-91. doi: 10.1242/jcs.118315. Epub 2013 Feb 27.







   April 2013        

Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.

Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R, Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N.

Neuron. 2013 Apr 24;78(2):298-311. doi: 10.1016/j.neuron.2013.02.025.


Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver.

Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V.

Cell Metab. 2013 Apr 2;17(4):586-98. doi: 10.1016/j.cmet.2013.03.003.


PMID: 23562079



Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer.

Knight JF, Lesurf R, Zhao H, Pinnaduwage D, Davis RR, Saleh SM, Zuo D, Naujokas MA, Chughtai N, Herschkowitz JI, Prat A, Mulligan AM, Muller WJ, Cardiff RD, Gregg JP, Andrulis IL, Hallett MT, Park M.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1301-10. doi: 10.1073/pnas.1210353110. Epub 2013 Mar 18.


PMID: 23509284






  February  2013      

ELF3 is a repressor of androgen receptor action in prostate cancer cells.

Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V.

Oncogene. 2014 Feb 13;33(7):862-71. doi: 10.1038/onc.2013.15. Epub 2013 Feb 25.


PMID: 23435425 


  January 2013          Development: New Wrinkles on Genetic Control of the MBT.
Lasko P.
Curr Biol. 2013 Jan 21;23(2):R65-7. doi: 10.1016/j.cub.2012.12.012.
PMID: 23347940

Translational control and autism-like behaviors.

Gkogkas CG, Sonenberg N.

Cell Logist. 2013 Jan 1;3(1):e24551. Epub 2013 Apr 4.


Autism-related deficits via dysregulated eIF4E-dependent translational control. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N.

Nature. 2013 Jan 17;493(7432):371-7. doi: 10.1038/nature11628. Epub 2012 Nov 21. PMID: 23172145 [PubMed - indexed for MEDLINE]


Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond. Deblois G, Giguère V. Nat Rev Cancer. 2013 Jan;13(1):27-36. doi: 10.1038/nrc3396. Epub 2012 Nov 29. Review. PMID: 23192231 [PubMed - indexed for MEDLINE]




  April 2013       

The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring GC/MS.

Mamer O, Gravel SP, Choinière L, Chénard V, St-Pierre J, Avizonis D.

Metabolomics. 2013;9:1019-1030. Epub 2013 Apr 17.



  November 2012      

PGC1α and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders.
Austin S, St-Pierre J.
J Cell Sci. 2012 Nov 1;125(Pt 21):4963-71. doi: 10.1242/jcs.113662.
PMID: 23277535


Loss of the par3 polarity protein promotes breast tumorigenesis and metastasis.

McCaffrey LM, Montalbano J, Mihai C, Macara IG.
Cancer Cell. 2012 Nov 13;22(5):601-14. doi: 10.1016/j.ccr.2012.10.003.
PMID: 23153534






   September 2012      

Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis.

von Roretz C, Jin Lian X, Macri AM, Punjani N, Clair E, Drouin O, Dormoy-Raclet V, Ma JF, Gallouzi IE.

Cell Death Differ. 2012 Sep 7. doi: 10.1038/cdd.2012.111.

[Epub ahead of print] PMID: 22955946




A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development.

Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N.

Mol Cell Biol. 2012 Sep;32(17):3585-93. Epub 2012 Jul 2.

PMID: 22751931 [PubMed - in process]



LKB1 and AMPK: central regulators of lymphocyte metabolism and function.

Blagih J, Krawczyk CM, Jones RG.

Immunol Rev. 2012 Sep;249(1):59-71. doi: 10.1111/j.1600-065X.2012.01157.x.

PMID: 22889215 [PubMed - in process]


  August 2012      

Tumor progression and metastasis: role of translational deregulation.

Nasr Z, Pelletier J.

Anticancer Res. 2012 Aug;32(8):3077-84.

PMID: 22843876 [PubMed - in process]



SnapShot: Endogenous RNAi Machinery and Mechanisms.

Flamand M, Duchaine TF.

Cell. 2012 Aug 3;150(3):662-662.e2.

No abstract available. PMID: 22863015 [PubMed - in process]


   July 2012      

Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.

Frank F, Hauver J, Sonenberg N, Nagar B.

EMBO J. 2012 Jul 31;31(17):3588-95. doi: 10.1038/emboj.2012.204.

Epub 2012 Jul 31. PMID: 22850669 [PubMed - in process]


Retrospective. Aaron Shatkin (1934-2012).
Sonenberg N, Filipowicz W.
Science. 2012 Jul 20;337(6092):309. No abstract available.

SnapShot: Endogenous RNA Pathways.
Flamand M, Duchaine TF.
Cell. 2012 Jul 20;150(2):442-442.e1. No abstract available. 

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N.
Mol Cell Biol. 2012 Jul 2. [Epub ahead of print]

The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase.
Sun Y, Atas E, Lindqvist L, Sonenberg N, Pelletier J, Meller A.
Nucleic Acids Res. 2012 Jul 1;40(13):6199-207. Epub 2012 Mar 28.

  June 2012      




Polarizing Macrophages through Reprogramming of Glucose Metabolism.


Blagih J, Jones RG.


Cell Metab. 2012 Jun 6;15(6):793-5.


PMID: 22682218 [PubMed - in process]

Uncoupling of PI3K from ErbB3 Impairs Mammary Gland Development but Does Not Impact on ErbB2-Induced Mammary Tumorigenesis.


Lahlou H, Müller T, Sanguin-Gendreau V, Birchmeier C, Muller WJ.


Cancer Res. 2012 Jun 15;72(12):3080-90. Epub 2012 Jun 4.


PMID: 22665265 [PubMed - in process]

The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice.
Di Marco S, Cammas A, Lian XJ, Kovacs EN, Ma JF, Hall DT, Mazroui R, Richardson J, Pelletier J, Gallouzi IE.
Nat Commun. 2012 Jun 12;3:896. doi: 10.1038/ncomms1899.

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.


Fabian MR, Sonenberg N.


Nat Struct Mol Biol. 2012 Jun 5;19(6):586-93. doi: 10.1038/nsmb.2296.


PMID: 22664986 [PubMed - in process]




  May 2012       

Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes.

Tabariès S, Dupuy F, Dong Z, Monast A, Annis MG, Spicer J, Ferri LE, Omeroglu A, Basik M, Amir E, Clemons M, Siegel PM.

Mol Cell Biol. 2012 May 29. [Epub ahead of print]

PMID: 22645303 [PubMed - as supplied by publisher]


Lysine acetylation: enzymes, bromodomains and links to different diseases.
You L, Nie J, Sun WJ, Zheng ZQ, Yang XJ.
Essays Biochem. 2012 May 25;52(1):1-12.

  March 2012      

CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis.
Ouellet V, Siegel PM.
J Cell Commun Signal. 2012 Mar 18. [Epub ahead of print]
PMID:  22427255  [PubMed - as supplied by publisher]

Modulation of leptin resistance by protein tyrosine phosphatases. 
St-Pierre J, Tremblay ML.
Cell Metab. 2012 Mar 7;15(3):292-7.
PMID:  22405067  [PubMed - in process]

Dynamics of receptor trafficking in tumorigenicity.
Parachoniak CA, Park M.
Trends Cell Biol. 2012 Mar 5. [Epub ahead of print]
PMID: 22397948 [PubMed - as supplied by publisher] 

Protein tyrosine phosphatases in cancer: friends and foes!  
Labbé DP, Hardy S, Tremblay ML.
Prog Mol Biol Transl Sci. 2012;106:253-306.

  February 2012      

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.  
Kundu P, Fabian MR, Sonenberg N, Bhattacharyya SN, Filipowicz W.
Nucleic Acids Res. 2012 Feb 23

An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.
Bongfen SE, Rodrigue-Gervais IG, Berghout J, Torre S, Cingolani P, Wiltshire SA, Leiva-Torres GA, Letourneau L, Sladek R, Blanchette M, Lathrop M, Behr MA, Gruenheid S, Vidal SM, Saleh M, Gros P.
PLoS One. 2012;7(2):e31012. Epub 2012 Feb 21

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.  
Vadnais C, Davoudi S, Afshin M, Harada R, Dudley R, Clermont PL, Drobetsky E, Nepveu A.
Nucleic Acids Res. 2012 Feb 8. [Epub ahead of print]


  January 2012      



Live imaging of the developing mouse mesonephros.


Grote D, Marcotte M, Bouchard M.


Methods Mol Biol. 2012;886:31-43.


PMID: 22639249 [PubMed - in process]

Loss of the 14-3-3σ Tumor Suppressor Is a Critical Event in ErbB2-Mediated Tumor Progression.


Ling C, Su VM, Zuo D, Muller WJ.


Cancer Discov. 2012 Jan;2(1):68-81. Epub 2011 Nov 29.


PMID: 22585169 [PubMed - in process

CUX1 transcription factors: From biochemical activities and cell-based assays to mouse models and human diseases
Hulea L, Nepveu A.
Gene. 2012 Apr 10;497(1):18-26. Epub 2012 Jan 28.
PMID: 22306263 [PubMed - in process]



PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.

Lessard L, Labbe DP, Deblois G, Begin LR, Hardy S, Mes-Masson AM, Saad F, Trotman LC, Giguere V, Tremblay ML.

Cancer Res. 2012 Jan 26. [Epub ahead of print]


PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply.
Klimcakova E, Chénard V, McGuirk S, Germain D, Avizonis DMuller WJSt-Pierre J.
Cancer Res. 2012 Jan 19. [Epub ahead of print]


Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival.

Robert F, Mills JR, Agenor A, Wang D, Dimarco S, Cencic R, Tremblay ML, Gallouzi IE, Hekimi S, Wing SS, Pelletier J.

Cancer Res. 2012 Jan 17. [Epub ahead of print]


Reconstitution of active and stoichiometric multisubunit lysine acetyltransferase complexes in insect cells.

Yan K, Wu CJ, Pelletier N, Yang XJ.

Methods Mol Biol. 2012;809:445-64.


Chromatin affinity purification.

Harada R, Nepveu A.

Methods Mol Biol. 2012;809:237-53.

  December 2011      

Epithelial organization, cell polarity and tumorigenesis.

McCaffrey LM, Macara IG.

Trends Cell Biol. 2011 Dec;21(12):727-35. Epub 2011 Jul 21


Estrogen-Related Receptor α, the Molecular Clock, and Transcriptional Control of Metabolic Outputs.

Giguère V, Dufour CR, Eichner LJ, Deblois G, Cermakian N.

Cold Spring Harb Symp Quant Biol. 2011 Dec 16.


Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain.

 Austin S, Klimcakova E, St-Pierre J.

Free Radic Biol Med. 2011 Dec 15;51(12):2243-8. Epub 2011 Sep 10.


DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin.

Kucharski TJ, Gamache I, Gjoerup O, Teodoro JG.

J Virol. 2011 Dec;85(23):12638-49. Epub 2011 Sep

  November 2011      

CEACAM1 deficiency delays important wound healing processes.

LeBlanc S, Arabzadeh A, Benlolo S, Breton V, Turbide C, Beauchemin N, Nouvion AL.

Wound Repair Regen. 2011 Nov;19(6):745-52. doi: 10.1111/j.1524-475X.2011.00742.x.

  October 2011       Breast cancer - one term, many entities?

Bertos NR, Park M.

J Clin Invest. 2011 Oct 3;121(10):3789-96. doi: 10.1172/JCI57100. Epub 2011 Oct 3. Review


  August 2011      

The colorectal tumor microenvironment: the next decade.

Beauchemin N.

Cancer Microenviron. 2011 Aug;4(2):181-5. Epub 2011 Jul 7

  June 2011      


Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2.

Boualia SK, Gaitan Y, Murawski I, Nadon R, Gupta IR, Bouchard M.

PLoS One. 2011;6(6):e21529. Epub 2011 Jun 24.


Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs.

Dufour CR, Levasseur MP, Pham NH, Eichner LJ, Wilson BJ, Charest-Marcotte A, Duguay D, Poirier-Héon JF, Cermakian N, Giguère V.

PLoS Genet. 2011 Jun;7(6):e1002143. Epub 2011 Jun 23.


PTPMT1: Connecting Cardiolipin Biosynthesis to Mitochondrial Function.
El-Kouhen K, Tremblay ML.
Cell Metab. 2011 Jun 8;13(6):615-7.

  May 2011       CCN3 Impairs Osteoblast and Stimulates Osteoclast Differentiation to Favor Breast Cancer Metastasis to Bone.
Ouellet V, Tiedemann K, Mourskaia A, Fong JE, Tran-Thanh D, Amir E, Clemons M, Perbal B, Komarova SV, Siegel PM.
Am J Pathol. 2011 May;178(5):2377-88.

  April 2011       mRNA helicases: the tacticians of translational control.
Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, Merrick WC, Sonenberg N.
Nat Rev Mol Cell Biol. 2011 Apr;12(4):235-45.


Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks.
Eichner LJ, Giguère V.
Mitochondrion. 2011 Apr 7. [Epub ahead of print]

  March 2011      

Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy.
Smolders L, Teodoro JG.
Expert Opin Ther Targets. 2011 Mar 5. [Epub ahead of print]

  February 2011       Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum.
Wang B, Nguyen M, Chang NC, Shore GC.
EMBO J. 2011 Feb 2;30(3):451-2.

  January 2011      

Inside the human cancer tyrosine phosphatome.
Julien SG, Dubé N, Hardy S, Tremblay ML.
Nat Rev Cancer. 2011 Jan;11(1):35-49.

Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure.
Sansregret L, Vadnais C, Livingstone J, Kwiatkowski N, Awan A, Cadieux C, Leduy L, Hallett MT, Nepveu A.
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1949-54. Epub 2011 Jan 18.

  December 2010      

Stromal retinoic acid receptor {beta} promotes mammary gland tumorigenesis.
Liu X, Nugoli M, Laferrière J, Saleh SM, Rodrigue-Gervais IG, Saleh M, Park M, Hallett MT, Muller WJ, Giguère V.
Proc Natl Acad Sci U S A. 2010 Dec 27. [Epub ahead of print]


Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease.
Deblois G, Giguère V.
Biochim Biophys Acta. 2010 Dec 21. [Epub ahead of print]


CEACAM1: a key regulator of vascular permeability.
Nouvion AL, Oubaha M, Leblanc S, Davis EC, Jastrow H, Kammerer R, Breton V, Turbide C, Ergun S, Gratton JP, Beauchemin N.
J Cell Sci. 2010 Dec 15;123(Pt 24):4221-30. Epub 2010 Nov 16

  November 2010       Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families.
Wu E, Thivierge C, Flamand M, Mathonnet G, Vashisht AA, Wohlschlegel J, Fabian MR, Sonenberg N. Duchaine TF.
Mol Cell. 2010 Nov 24;40(4):558-70.

Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes.
Tabariès S, Dong Z, Annis MG, Omeroglu A, Pepin F, Ouellet V, Russo C, Hassanain M, Metrakos P, Diaz Z, Basik M, Bertos N, Park M, Guettier C, Adam R, Hallett M, Siegel PM.
Oncogene. 2010 Nov 15. Epub ahead of print

Genetic analysis of B55{alpha}/Cdc55 PP2A subunits: Association with the adenovirus E4orf4 protein.
Zhang Z, Mui MZ, Chan F, Roopchand DE, Marcellus RC, Blanchette P, Li S, Berghuis AM, Branton PE.
J Virol. 2010 Nov 3. Epub ahead of print

  October 2010      

Transcriptional control of the ERBB2 amplicon by ERR{alpha} and PGC-1{beta} promotes mammary gland tumorigenesis.
Deblois G, Chahrour G, Perry MC, Sylvain-Drolet G, Muller WJ, Giguère V.
Cancer Res. 2010 Oct 20.

Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.
Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, Denardo D, Coussens LM, Brennan DJ, Gallagher WM, Park M, Pawson T, Hallett M, Muller WJ.
Cancer Res. 2010 Oct 15;70(20):7776-87.

miR-378(∗) Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway.
Eichner LJ, Perry MC, Dufour CR, Bertos N, Park M, St-Pierre J, Giguère V.
Cell Metab. 2010 Oct 6;12(4):352-61.

Receptor Tyrosine Kinase Signaling Favors a Protumorigenic State in Breast Cancer Cells by Inhibiting the Adaptive Immune Response.
Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, Denardo D, Coussens LM, Brennan DJ, Gallagher WM, Park M, Pawson T, Hallett M, Muller WJ.
Cancer Res. 2010 Oct 5. [Epub ahead of print]


  September 2010      

In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis.
Stuible M, Tremblay ML.
Trends Cell Biol. 2010 Sep 21. [Epub ahead of print]

The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice.
Yanagiya A, Delbes G, Svitkin YV, Robaire B, Sonenberg N.
J Clin Invest. 2010 Sep 1;120(9):3389-400. doi: 10.1172/JCI43350. Epub 2010 Aug 25.

Tudor domain.
Lasko P.
Curr Biol. 2010 Aug 24;20(16):R666-7. No abstract available.

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.
Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B.
BMC Dev Biol. 2010 Aug 20;10:89

  August 2010      

Congratulations to Dr. Nicole Beauchemin
for the success of the
20th Annual International CEA Symposium that was held from August 8 -11th.
The GCRC thanks Dr. Beauchemin and her team
for their excellence in organizing this year’s symposium.
Read CEA Symposium Report

Recent Selected Publications from GCRC

{beta}1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression.
Huck L, Pontier SM, Zuo DM, Muller WJ.
Proc Natl Acad Sci U S A. 2010 Aug 16. [Epub ahead of print]

ADAM10 Releases a Soluble Form of the GPNMB/Osteoactivin Extracellular Domain with Angiogenic Properties.
Rose AA, Annis MG, Dong Z, Pepin F, Hallett M, Park M, Siegel PM.
PLoS One. 2010 Aug 10;5(8). pii: e12093.

4E-BPs at the crossroads of oncogenic MAPK and AKT signaling.
Topisirovic I, Sonenberg N.
Pigment Cell Melanoma Res. 2010 Aug 5.

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.
Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N.
Proc Natl Acad Sci U S A. 2010 Aug 2. [Epub ahead of print]

Metastasis of Colorectal Cancer

This is the title of a new book dedicated to all colorectal cancer patients. Edited by Dr. Nicole Beauchemin of the Goodman Cancer Research Centre and Dr. Jacques Huot of Le Centre de recherche en cancérologie de l'Université Laval, this new book will be released by Springer in October 2010.  Read the first five pages.

  July 2010      

We are proud to announce that  Dr. Nahum Sonenberg
has been appointed to the
Order of Canada.

The Order of Canada is the centrepiece of Canada’s honours system and recognizes a lifetime of outstanding achievement, dedication to the community and service to the nation. The Goodman Cancer Research Centre is honoured to congratulate Dr. Sonenberg for his success.
Read the Governor General’s News Release

Read the McGill News Release


Recent Selected Publications from GCRC

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation.
Bungard D, Fuerth BJ, Zeng PY, Faubert B, Mass NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL.
Science. 2010 Jul 15. [Epub ahead of print]

The three-dimensional architecture of Hox cluster silencing.
Ferraiuolo MA, Rousseau M, Miyamoto C, Shenker S, Wang XQ, Nadler M, Blanchette M, Dostie J.
Nucleic Acids Res. 2010 Jul 25. [Epub ahead of print]

  June 2010      

Receptor tyrosine phosphatase sigma (RPTPsigma) regulates, p250GAP, a novel substrate that attenuates Rac signaling.
Chagnon MJ, Wu CL, Nakazawa T, Yamamoto T, Noda M, Blanchetot C, Tremblay ML.
Cell Signal
. 2010 Jun 12. [Epub ahead of print]


  May 2010      

Dr. Moshe Szyf is honoured for his work in epigenetics
Dr. Moshe Szyf,Associate Member of the GCRC and
James McGill Professor in the
Department of Pharmacology and
, has been awarded the title of Radio-Canada Scientist of the Year 2009 for his pioneering work into how our environment can alter the way our DNA expresses genes. The Goodman Cancer Research Centre is extremely proud to congratulate Dr. Szyf for his great success.
McGill Press Release

Recent Selected Publications from GCRC

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu  Y, Kozma SC, Thomas G, Sonenberg N.
. 2010 May 28;328(5982):1172-6.

Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Frank F, Sonenberg N, Nagar B.
Nature. 2010 May 26. [Epub ahead of print]

A novel role for 14-3-3sigma in regulating epithelial cell polarity.
Ling C, Zuo D, Xue B, Muthuswamy S, Muller WJ.
Genes Dev. 2010 May;24(9):947-56

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor {alpha}
Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V.
Mol Endocrinol. 2010 May 19. [Epub ahead of print]

Cysteamine, the molecule used to treat cystinosis, potentiates the anti-malarial efficacy of artemisinin.
Min-Oo G, Fortin A, Poulin JF, Gros P.
Antimicrob Agents Chemother. 2010 May 17. [Epub ahead of print]

Mechanisms governing the control of mRNA translation.
Livingstone M, Atas E, Meller A, Sonenberg N
Phys Biol. 2010 May 12;7(2):021001

  April 2010      

We are proud to announce that Dr. Michel L.Tremblay
and his McGill University team,
Dr. Bruno Gagnon and Dr. Neil McDonald,
have been awarded the CRS/Rob Lutterman Pancreatic Cancer Research Grant in support of their project entitled:
"Linking cancer anorexia-cachexia syndrome, resting energy expenditure and chronic inflammation state in patients with pancreatic cancer through cellular metabolic mechanisms and their unique metastatic control."

Read The Cancer Research Society's Announcement
Read the Gazette Aritcle


Announcing the 2010-2011 FRSQ Award Recipients
from the GCRC

Recent Selected Publications from GCRC

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression.
Dillon RL,  Muller WJ.
Cancer Res. Cancer Res. 2010 Jun 1;70(11):4260-4. Epub 2010 Apr 27.

Overexpression of Galectin-7, A Myoepithelial Cell Marker, Enhances Spontaneous Metastasis of Breast Cancer Cells.
Demers M, Rose AA, Grosset AA, Biron-Pain K, Gaboury L, Siegel PM, St-Pierre Y.
Am J Pathol. 2010 Apr 9.[Epub ahead of print]

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing.
Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ.
Nucleic Acids Res. 2010 Apr 22.[Epub ahead of print]

  March 2010      

Recent Selected Publications from GCRC

The Gab1 scaffold regulates RTK-dependent dorsal ruffle formation through the adaptor Nck. Abella JV, Vaillancourt R, Frigault MM, Ponzo MG, Zuo D, Sangwan V, Larose L, Park M.
Cell Sci. 2010 Apr 15;123(Pt 8):1306-19. Epub 2010 Mar 23.

The Antidepressant Sertraline Inhibits Translation Initiation by Curtailing Mammalian Target of Rapamycin Signaling. Lin CJ, Robert F, Sukarieh R, Michnick S, Pelletier J
Cancer Res. 2010 Apr 15;70(8):3199-208. Epub 2010 Mar 30.

Transcription factor regulatory networks in mammary epithelial development and tumorigenesis.
Siegel PM, Muller WJ.
Oncogene. 2010 May 13;29(19):2753-9. Epub 2010 Mar 29. Review.

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission.
Bidinosti M, Ran I, Sanchez-Carbente MR, Martineau Y, Gingras AC, Gkogkas C, Raught B, Bramham CR, Sossin WS, Costa-Mattioli M, DesGroseillers L, Lacaille JC, Sonenberg N.
Mol Cell. 2010 Mar 26;37(6):797-808

Dissecting the role of mTOR: Lessons from mTOR inhibitors.
Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N.
Biochim Biophys Acta. 2010 Mar;1804(3):433-9.

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer. Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ.
Oncogene. 2010 Mar 22 [Epub ahead of print]

The met receptor tyrosine kinase and basal breast cancer.
Ponzo MG, Park M.
Cell Cycle. 2010 Mar 24;9(6).

The roles of CUX1 homeodomain proteins in the establishment of a transcriptional program required for cell migration and invasion.
Kedinger V, Nepveu A.
Cell Adh Migr. 2010 Jul 4;4(3). [Epub ahead of print]

Glycoprotein Nonmetastatic B Is an Independent Prognostic Indicator of Recurrence and a Novel Therapeutic Target in Breast Cancer.
Rose AA et al.
Clin Cancer Res. Apr 1;16(7):2147-56. Epub 2010 Mar 9

Replication initiation and DNA topology: The twisted life of the origin.
Rampakakis E, Gkogkas C, Di Paola D, Zannis-Hadjopoulos M.
J Cell Biochem. 2010 Mar 8.

Cell biology. Burn out or fade away? Topisirovic I, Sonenberg N.
Science. 2010 Mar 5;327(5970):1210-1. No abstract available

The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions. Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Giguère V.
Genes Dev. 2010 Mar 15;24(6):537-42. Epub 2010 Mar 1.

  February 2010      

Recent Selected Publications from GCRC

Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
Min-Oo G et al.
Exp Parasitol. 2010 Feb 26. [Epub ahead of print]

Regulation of Drosophila Vasa in vivo through paralogous Cullin-RING E3 ligase specificity receptors.
Kugler JM, Woo JS, Oh BH, Lasko P.
Mol Cell Biol. 2010 Apr;30(7):1769-82. Epub 2010 Feb 1

Adenovirus Protein E4orf4 Induces Premature APCCdc20 Activation in Saccharomyces cerevisiae by a PP2A-Dependent Mechanism. Mui MZ et al.
J Virol. 2010 Feb 17.
[Epub ahead of print]

  January 2010      

Recent Selected Publications from GCRC

Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. Hassan SW et al.
PLoS One. 2010 Jan 25;5(1):e8868

Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B.
Shahbazian D et al.
Mol Cell Biol.  2010 Mar;30(6):1478-85. Epub 2010 Jan 19

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Alain T et al.
Proc Natl Acad Sci U S A. 2010 Jan 4.

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Alain T et al.
Proc Natl Acad Sci U S A. 2010 Jan 4.

Insufficient milk supply and breast cancer risk: a systematic review. Cohen JM et al.
PLoS One. ;4(12):e8237

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. Chang NC et al.
EMBO J. [Epub ahead of print]

Emerging therapeutic targets in breast cancer bone metastasis. Rose AA, Siegel PM.
Future Oncol. 2010 Jan;6(1):55-74

CrkII Transgene Induces Atypical Mammary Gland Development and Tumorigenesis. Fathers KE et al.
Am J Pathol. 2010 Jan;176(1):446-60

Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. Di Paola D et al.
Nucleic Acids Res. 2010 Jan 11.

Regulation of cell signalling by uPAR. Smith HW, Marshall CJ.
Nat Rev Mol Cell Biol. 2010 Jan;11(1):23-36

  December 2009      

Recent Selected Publications from GCRC

Dissecting the role of mTOR: Lessons from mTOR inhibitors. Dowling RJ et al.
Biochim Biophys Acta. 2009 Dec 11

14-3-3 proteins function in the initiation and elongation steps of DNA replication in Saccharomyces cerevisiae. Yahyaoui W, Zannis-Hadjopoulos M.
J Cell Sci. 2009 Dec 10;122(Pt 24):4419-26.

Apoptosis: it's BAK to VDAC. Shore GC.
EMBO Rep. 2009 Dec;10(12):1311-3. No abstract available.

Vasa promotes Drosophila germline stem cell differentiation by activating mei-P26 translation by directly interacting with a (U)-rich motif in its 3' UTR. Liu N, Han H, Lasko P.
Genes Dev. 2009 Dec 1;23(23):2742-52.

Origins and evolution of the mechanisms regulating translation initiation in eukaryotes. Hernández G, Altmann M, Lasko P.
Trends Biochem Sci. 2009 Nov 17

Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3. Meunier C et al.
Oncogene. 2009 Nov 16

Physiological Genomics Identifies Estrogen-Related Receptor {alpha} as a Regulator of Renal Sodium and Potassium Homeostasis and the Renin-Angiotensin Pathway. Tremblay AM et al.
Mol Endocrinol. 2009 Nov 9.

  November 2009      

Dr. Nahum Sonenberg  has been named
the 2009 Health Researcher of the Year
in Biomedical and Clinical Research by
the Canadian Institutes of Health Research (CIHR).

The GCRC is proud to congratulate Dr. Sonenberg for winning this prestigious award for his pioneering study and analysis of translation control mechanisms, the process by which the genetic information stored in our DNA is turned into proteins. His research has opened the door to new treatments for diseases such as cancer and HIV/AIDS.
Read Canadian Institutes of Health Research Article
Read Canada's Health Researcher of the year in Biomedical and Clinical Research - CIHR  Article


GCRC researchers identify key genetic factors
which can lead to cancer

The GCRC congratulates Dr.Petroulakis, of Dr. Nahum Sonenberg's laboratory and first author of the study, for the discovery of a previously unknown series of interactions between genes that control whether cells become cancerous.
Read Publication:
p53-dependent translational control of senescence and transformation via 4E-BPs. Petroulakis E et al Cancer Cell. 2009 Nov 6;16(5):439-46.

Read McGill Press Release

5th QTRN Annual Symposium 2009

Recent Selected Publications from GCRC

The two faces of PTP1B in cancer. Lessard L et al
Biochim Biophys Acta. 2009 Sep 24.

Translation initiation: a critical signalling node in cancer. Robert F., Pelletier J.
Expert Opin Ther Targets. 2009 Aug 26.

Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types. Cadieux C et al.
Cancer Res. 2009 Sep 15;69(18):7188-97

  October 2009      

Dr. Vincent Giguère to be inducted as an RSC Fellow 

The Goodman Cancer Research Centre is immensely proud to announce that Dr. Vincent Giguère has been elected as a Fellow to the Royal Society of Canada. The GCRC congratulates Dr. Giguère for this honor in recognition of his excellence in scientific research in the field of nuclear receptors.
Read the Royal Society of Canada New Fellows 2009 Citation
Read the McGill University News Article

Recent Selected Publications from GCC

Could stress granules be involved in age-related diseases? Gallouzi IE.
Aging (Albany NY). 2009 Sep 21;1(9):753-7. No abstract available

Tristetraprolin: a weapon against HPV-induced cervical cancer? Gallouzi IE, Di Marco S.
Aging (Albany NY). 2009 Oct 8;1(10):839-41.

  September 2009      

Recent Selected Publications from GCC

Could stress granules be involved in age-related diseases? Gallouzi IE.
Aging (Albany NY). 2009 Sep 21;1(9):753-7. No abstract available

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression. Ranger JJ et al
Cancer Res. 2009 Sep 1;69(17):6823-30.

RNA interference and micro rna -oriented therapy in cancer: rationales, promises, and challenges.
Duchaine TF, Slack FJ.
Curr Oncol. 2009 Aug;16(4):61-6

Current status and challenges associated with targeting mTOR for cancer therapy. Dowling RJ et al.
BioDrugs. 2009;23(2):77-91

  August 2009      



(Announcement) For a few years now, progress in the field of genetics has been spectacular. There remain however, numerous unexplored paths that fascinate researchers, including Philippe Gros. His discoveries earned him the 2008 Prix Wilder-Penfield, awarded by the Quebec government. A few months ago he also won the prestigious Killam Prize in the Health Sciences category, which included a $100,000 grant. Philippe Gros is one of the principal investigators at McGill University’s Life Sciences Complex, newly opened last year. He leads the Complex Traits Group. He and his team are exploring the interaction between environmental factors and genes that predispose to disease. He is also a tenured professor in the Department of Biochemistry at the same university. To underline the remarkable contributions of Philippe Gros towards the understanding of human health, La Presse and Radio-Canada have named him personality of the week. Radio Canada Link

  July 2009      

Recent Selected Publications from GCC

Genome-Wide Identification of Direct Target Genes Implicates Estrogen-Related Receptor {alpha} as a Determinant of Breast Cancer Heterogeneity. Deblois G et al.
Cancer Res. 2009 Jul 21.

Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Ponzo MG et al.
Proc Natl Acad Sci U S A. 2009 Jul 17.

Current status and challenges associated with targeting mTOR for cancer therapy. Dowling RJ et al.
BioDrugs. 2009;23(2):77-91.

The Adenovirus E4orf4 Protein Induces G2/M Arrest and Cell Death by Blocking PP2A Activity Regulated by the B55 Subunit. Li S et al
J Virol. 2009 Jun 17.

Calcineurin a-binding protein, a novel modulator of the calcineurin-nuclear factor of activated T-cell signaling pathway, is overexpressed in wilms' tumors and promotes cell migration. Nguyen AH et al
Mol Cancer Res. 2009 Jun;7(6):821-31. Epub 2009 Jun 16.

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Dillon RL et al.
Cancer Res. 2009 Jun 15;69(12):5057-64.


  June 2009      

Plumbing in the embryo: developmental defects of the urinary tracts.  Uetani N, Bouchard M.
Clin Genet. 2009 Apr;75(4):307-17.

GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Dydensborg AB et al. Oncogene. 2009 Jun 1. [Epub ahead of print]

Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases. Abella JV, Park M.
Am J Physiol Endocrinol Metab. 2009 May;296(5):E973-84. Epub 2009 Feb 24.

  May 2009      

Dr. Phillippe Gros is honored by the Killam Trust for his achievements in Health Sciences

The Goodman Cancer Centre is immensely proud to announce that Dr. Philippe Gros is a recipient of the Killam Prize 2009 for Health Sciences. The GCC congratulates Dr. Gros for this prestigious recognition.
Read the Canada Council for the Arts Announcement
View the Killam Prize Event


Recent Selected Publications from GCC

In Memorial of Dr. Annette Herscovics:
Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity. Rodionov D et al.
Protein Expr Purif. 2009 Jul;66(1):1-6. Epub 2009 Feb 26.

  April 2009      

Recent Selected Publications from GCC

Tumor suppressors and cell metabolism: a recipe for cancer growth.  Jones RG et al.
Genes Dev. 2009 Mar 1;23(5):537-48.

HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain Gingras, MC et al.
PLoS ONE. 2009;4(4):e5105.

We are delighted to extend our congratulations to Mr. Greg Finak for being named this year's winner of the Marilyn Wener Foundation Merit Award. His publication entitled 'Stromal gene expression predicts clinical outcome in breast cancer' has been selected as the best for 2008.

  March 2009      

Recent Selected Publications from GCC

Metazoan origins of DNA replication: Regulation through dynamic chromatin structure. Rampakakis E. et al.
J Cell Biochem. 2009 March 01.

Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Sonenberg N, Hinnebusch AG.
Cell. 2009 Feb 20;136(4):731-45.

  February 2009      

Recent Selected Publications from GCC

The PTP family photo album. Tremblay ML. 2009.
Cell. 136(2):213-4.

CUX1 Transcription Factor Is a Downstream Effector of the Proteinase-activated Receptor 2 (PAR2).
Wilson BJ, Harada R, Leduy L, Hollenberg MD, Nepveu A.
J Biol Chem. 2009 Jan 2;284(1):36-45. Epub 2008 Oct 24.

  January 2009      

Recent Selected Publications from GCC

Integrins in mammary-stem-cell biology and breast-cancer progression - a role in cancer stem cells?
Pontier SM, Muller WJ.
J Cell Sci. 2009 Jan 15;122(Pt 2):207-14.

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction.
Grote D, Boualia SK, Souabni A, Merkel C, Chi X, Costantini F, Carroll T, Bouchard M.
PLoS Genet. 2008 Dec;4(12):e1000316. Epub 2008 Dec 26.

The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen activated protein kinase inactivation.
Hallé M, Gomez MA, Stuible M, Shimizu H, McMaster WR, Olivier M, Tremblay ML.
J Biol Chem. 2008 Dec 8.

Two Goodman Cancer Centre researchers  are honored by Quebec Science magazine!

Congratulations to Morag Park for her paper on 'Tumor Micro Environment' and to Janusz Rak (Associate Member) for his paper on 'Cancer Cell Movement'. Their respective groundbreaking work has earned the prestigious honour of Québec Science's Top Ten Discoveries. (read more)

  November 2008      

Congratulations to Dr. Philippe Gros upon his exceptional achievement! Philippe Gros receives the Wilder-Penfield prize, Prix du Québec 2008, in the biomedical sciences for his advances in resistance to treatment or susceptibility to devastating diseases. (read more)


April 2008


Dr. Nahum Sonenberg receives the prestigious Gairdner International Award for the outstanding contributions to the field of medical science (read more ).

  November 2007       McGill Cancer Centre is proud to announce recent publiction  by Dr. Annette Herscovics in MBC. The article can be read here

  September 2007      

McGill Cancer Centre is proud to announce recent publictions by two of itis researchers. First by Dr. Annette Herscovics in BBRC on Stimulation of ERAD and by Dr. Thomas F. Duchaine on Microrna inhibition of Translationin Science

  January 2007:       Michel L. Tremblay’s research team discovers the link between PTP1B and tumorigenesis and metastasis. Nature Genetics. Media Reports: McGill Newsroom, La Presse

  November 2006:       Workshop on "Challenges in the discovery and development of targeted therapies". Experts from academia, clinic and industry brainstorm regarding future directions

  November 2006:       Dr. Michel L. Tremblay elected a fellow of the Royal Society of Canada

Inaugural Joint Conference
September 10-13, 2006

research2The inaugural conference entitled The McGill Cancer Centre and the Weizmann Institute of Science 1st Annual Conference on “Molecular Mechanisms of Tumorigenesis” was held on September 10-13, 2006 and took place at the McGill University Faculty Club in Montreal. The meeting brought together top scientists from both institutions.

Many governmental, university and industry officials  supported and joined the scientists  at the opening dinner ceremony. Thanks to our sponsors and contributors, the dynamics and the high caliber of the program The conference drew more that 150 attendees.

This conference gave the GCRC the opportunity to share the novel research brought by the team from the Weizmann with the Montreal community. Indeed, on the second evening of the conference, the scientists addressed the public with pertinent issues regarding different areas of the cancer disease. This public event was attended by close to 200 people.

  April 2006:       Dr. Nahum Sonenberg elected to the American Academy of Arts and Sciences