January

Serine Is an Essential Metabolite for Effector T Cell Expansion.
Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG.
Cell Metab. 2017 Jan 12. pii: S1550-4131(16)30644-1. doi: 10.1016/j.cmet.2016.12.011. [Epub ahead of print]
PMID: 28111214

Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer.
Audet-Walsh É, Yee T, McGuirk S, Vernier M, Ouellet C, St-Pierre J, Giguère V.
Cancer Res. 2017 Jan 15;77(2):378-389. doi: 10.1158/0008-5472.CAN-16-1204.
PMID: 27821488

Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
Giménez-Mascarell P, Oyenarte I, Hardy S, Breiderhoff T, Stuiver M, Kostantin E, Diercks T, Pey AL, Ereño-Orbea J, Martínez-Chantar ML, Khalaf-Nazzal R, Claverie-Martin F, Müller D, Tremblay ML, Martínez-Cruz LA.
J Biol Chem. 2017 Jan 20;292(3):786-801. doi: 10.1074/jbc.M116.759944.
PMID: 27899452

December

MAPK Pathway Inhibitors Sensitize BRAF-Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB.
Rose AA, Annis MG, Frederick DT, Biondini M, Dong Z, Kwong L, Chin L, Keler T, Hawthorne T, Watson IR, Flaherty KT, Siegel PM.
Clin Cancer Res. 2016 Dec 15;22(24):6088-6098.
PMID: 27515299

 

November

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies.
Quail DF, Joyce JA.
Clin Cancer Res. 2016 Nov 28. doi: 10.1158/1078-0432.CCR-16-0133. [Epub ahead of print]
PMID: 27895033

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.
Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A.
Sci Transl Med. 2016 Nov 16;8(365):365ra159.
PMID: 27856798

Proposing a mechanism of action for ataluren.
Siddiqui N, Sonenberg N.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12353-12355. No abstract available.
PMID: 27791186
 

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.
Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367.
PMID: 27791185

September

The p53 status can influence the role of Sam68 in tumorigenesis.
Li N, Ngo CT, Aleynikova O, Beauchemin N, Richard S.
Oncotarget. 2016 Sep 28. doi: 10.18632/oncotarget.12305. [Epub ahead of print]
PMID: 27690217

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
Carbonneau M, M Gagné L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot MÉ, Mallette FA.
Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700.
PMID: 27624942

5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.
Rajadurai CV, Havrylov S, Coelho PP, Ratcliffe CD, Zaoui K, Huang BH, Monast A, Chughtai N, Sangwan V, Gertler FB, Siegel PM, Park M.
J Cell Biol. 2016 Sep 12;214(6):719-34. doi: 10.1083/jcb.201501003. Epub 2016 Sep 5.
PMID: 27597754

Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.
Lévesque N, Christensen KE, Van Der Kraak L, Best AF, Deng L, Caldwell D, MacFarlane AJ, Beauchemin N, Rozen R.
Mol Carcinog. 2016 Sep 6. doi: 10.1002/mc.22568. [Epub ahead of print]
PMID: 27597531

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis.
Lehuédé C, Dupuy F, Rabinovitch R, Jones RG, Siegel PM.
Cancer Res. 2016 Sep 15;76(18):5201-8. doi: 10.1158/0008-5472.CAN-16-0266. Epub 2016 Sep 1. Review.
PMID: 27587539

Metabolomics Analyses of Cancer Cells in Controlled Microenvironments.
Gravel SP, Avizonis D, St-Pierre J.
Methods Mol Biol. 2016;1458:273-90. doi: 10.1007/978-1-4939-3801-8_20.
PMID: 27581029

CRISPR/Cas9 Genome Editing as a Strategy to Study the Tumor Microenvironment in Transgenic Mice.
Yamanaka Y.
Methods Mol Biol. 2016;1458:261-71. doi: 10.1007/978-1-4939-3801-8_19.
PMID: 27581028

Detecting Secreted Analytes from Immune Cells: An Overview of Technologies.
Pike KA, Hui C, Krawczyk CM.
Methods Mol Biol. 2016;1458:111-24. doi: 10.1007/978-1-4939-3801-8_9.
PMID: 27581018

Laser Capture Microdissection as a Tool to Study Tumor Stroma.
Bertos NR, Park M.
Methods Mol Biol. 2016;1458:13-25. doi: 10.1007/978-1-4939-3801-8_2.
PMID: 27581011
 

August

Expression of DRD2 is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice.
Jandaghi P, Najafabadi HS, Bauer AS, Papadakis AI, Fassan M, Hall A, Monast A, von Knebel Doeberitz M, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Sipos B, Auld D, Lathrop M, Park M, Büchler MW, Strobel O, Hackert T, Giese NA, Zogopoulos G, Sangwan V, Huang S, Riazalhosseini Y, Hoheisel JD.
Gastroenterology. 2016 Aug 28. pii: S0016-5085(16)34982-4. doi: 10.1053/j.gastro.2016.08.040. [Epub ahead of print]

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo.
Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, Logsdon M, Brandner J, Tiegs G, Beauchemin N, Wagener C, Deppert W, Horst AK.
Oncotarget. 2016 Aug 27. doi: 10.18632/oncotarget.11650. [Epub ahead of print]

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.
Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu HH, Everts B, Pearce EJ, Lupien M, White JH, Krawczyk CM.
Cell Rep. 2016 Aug 16;16(7):1829-37. doi: 10.1016/j.celrep.2016.07.026. Epub 2016 Aug 4.
PMID: 27498878  Free Article

The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism.
Izreig S, Samborska B, Johnson RM, Sergushichev A, Ma EH, Lussier C, Loginicheva E, Donayo AO, Poffenberger MC, Sagan SM, Vincent EE, Artyomov MN, Duchaine TF, Jones RG.
Cell Rep. 2016 Aug 16;16(7):1915-28. doi: 10.1016/j.celrep.2016.07.036. Epub 2016 Aug 4.
PMID: 27498867

Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.
Wang W, Cencic R, Whitesell L, Pelletier J, Porco JA Jr.
Chemistry. 2016 Aug 16;22(34):12006-10. doi: 10.1002/chem.201602953. Epub 2016 Jul 15.
PMID: 27338157

The role of claudins in cancer metastasis.
Tabariès S, Siegel PM.
Oncogene. 2016 Aug 15. doi: 10.1038/onc.2016.289.

MAPK Pathway Inhibitors Sensitize BRAF Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB.
Rose AA, Annis MG, Frederick DT, Biondini M, Dong Z, Kwong LN, Chin L, Keler T, Hawthorne T, Watson IR, Flaherty KT, Siegel PM.
Clin Cancer Res. 2016 Aug 11. pii: clincanres.1192.2016. [Epub ahead of print]
PMID: 27515299

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.
Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA.
Cell. 2016 Aug 11;166(4):963-76. doi: 10.1016/j.cell.2016.06.056. Epub 2016 Jul 28.
PMID: 27477511

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.
Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ.
Genes Dev. 2016 Aug 1;30(15):1698-703. doi: 10.1101/gad.282756.116. Epub 2016 Aug 4.
PMID: 27492367
 

July

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L.
Pedanou VE, Gobeil S, Tabariès S, Simone TM, Zhu LJ, Siegel PM, Green MR.
Elife. 2016 Jul 29;5. pii: e16844. doi: 10.7554/eLife.16844.
PMID: 27472901

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.
Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, R Calderon M, Sonenberg N, Haghighi AP.
Nat Commun. 2016 Jul 19;7:12188. doi: 10.1038/ncomms12188.
PMID: 27432119 Free PMC Article

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells.
Bhat M, Yanagiya A, Graber T, Razumilava N, Bronk S, Zammit D, Zhao Y, Zakaria C, Metrakos P, Pollak M, Sonenberg N, Gores G, Jaramillo M, Morita M, Alain T.
Oncotarget. 2016 Jul 18. doi: 10.18632/oncotarget.10671. [Epub ahead of print]
PMID: 27447552 Free Article

Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer.
Chu J, Cargnello M, Topisirovic I, Pelletier J.
Trends Cell Biol. 2016 Jul 14. pii: S0962-8924(16)30076-9. doi: 10.1016/j.tcb.2016.06.005. [Epub ahead of print] Review.
PMID: 27426745

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.
Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V.
Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156.
PMID: 27402251

June

Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function.
Balmer ML, Ma EH, Bantug GR, Grählert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener AV, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C.
Immunity. 2016 Jun 21;44(6):1312-24. doi: 10.1016/j.immuni.2016.03.016. Epub 2016 May 17.


Nucleus to Mitochondria: Lost in Transcription, Found in Translation.
St-Pierre J, Topisirovic I.
Dev Cell. 2016 Jun 20;37(6):490-2. doi: 10.1016/j.devcel.2016.06.003.
PMID: 27326927

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.
Tsukumo Y, Alain T, Fonseca BD, Nadon R, Sonenberg N.
Nat Commun. 2016 Jun 20;7:11776. doi: 10.1038/ncomms11776.
PMID: 27319316 Free PMC Article

Translational control by 5'-untranslated regions of eukaryotic mRNAs.
Hinnebusch AG, Ivanov IP, Sonenberg N.
Science. 2016 Jun 17;352(6292):1413-6. doi: 10.1126/science.aad9868. Review.
PMID: 27313038


New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology.
Roulston A, Shore GC.
Mol Cell Oncol. 2015 Jun 10;3(1):e1052180. doi: 10.1080/23723556.2015.1052180. eCollection 2016 Jan. Review.
PMID: 27308565 Free PMC Article

May

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.
So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA.
Sci Signal. 2016 May 31;9(430):ra57. doi: 10.1126/scisignal.aad8463.
PMID: 27245614

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ES, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.
Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4.
PMID: 27043414

April

Targeting tumor microenvironment in cancer therapy.
Singh SR, Rameshwar P, Siegel P.
Cancer Lett. 2016 Apr 7. pii: S0304-3835(16)30222-1. doi: 10.1016/j.canlet.2016.04.009. [Epub ahead of print] No abstract available.
PMID: 27060765

Lineage specification in the mouse preimplantation embryo.
Chazaud C, Yamanaka Y.
Development. 2016 Apr 1;143(7):1063-74. doi: 10.1242/dev.128314. Review.
PMID: 27048685

March

PTP1B deficiency enables the ability of a high fat diet to drive the invasive character of PTEN-deficient prostate cancers.
Labbe DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, Sirois J, Haigh J, Bégin LR, Trotman LC, Paquet M, Tremblay ML.
Cancer Res. 2016 Mar 28. pii: canres.1501.2015. [Epub ahead of print]
PMID: 27020859

Localizing PRL-2 expression and determining the effects of dietary Mg2+ on expression levels.
Gungabeesoon J, Tremblay ML, Uetani N.
Histochem Cell Biol. 2016 Mar 25. [Epub ahead of print]
PMID: 27015884

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.
Skałecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J.
Dev Neurobiol. 2016 Mar 23. doi: 10.1002/dneu.22392. [Epub ahead of print]

Chordin-like 1 suppresses BMP4-induced breast cancer cell migration and invasion.
Cyr-Depauw C, Northey JJ, Tabariès S, Annis MG, Dong Z, Cory S, Hallett M, Rennhack JP, Andrechek ER, Siegel PM.
Mol Cell Biol. 2016 Mar 14. pii: MCB.00600-15. [Epub ahead of print]
PMID: 26976638

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.
Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I.
Genome Res. 2016 Mar 16. [Epub ahead of print]
PMID: 26984228 Free Article

Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.
Van Der Kraak L, Langlais D, Jothy S, Beauchemin N, Gros P.
Mamm Genome. 2016 Mar 15. [Epub ahead of print]
PMID: 26979842

Inhibition of the PRL-2/CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth.
Kostantin E, Hardy S, Valinsky WC, Kompatscher A, de Baaij JH, Zolotarov Y, Landry M, Uetani N, Martinez-Cruz LA, Hoenderop JG, Shrier A, Tremblay ML.
J Biol Chem. 2016 Mar 11. pii: jbc.M115.705863. [Epub ahead of print]
PMID: 26969161 Free Article

Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia.
Penafuerte CA, Gagnon B, Sirois J, Murphy J, MacDonald N, Tremblay ML.
Br J Cancer. 2016 Mar 15;114(6):680-7. doi: 10.1038/bjc.2016.3. Epub 2016 Mar 8.
PMID: 26954714

Regulation of cell migration and β1 integrin trafficking by the endosomal adaptor GGA3.
Ratcliffe CD, Sahgal P, Parachoniak CA, Ivaska J, Park M.
Traffic. 2016 Mar 3. doi: 10.1111/tra.12390. [Epub ahead of print]
PMID: 26935970

Rab11-FIP1C is a critical negative regulator in ErbB2-mediated mammary tumor progression.
Boulay PL, Mitchell L, Turpin J, Huot-Marchand JÉ, Lavoie C, Sanguin-Gendreau V, Jones L, Mitra S, Livingstone JM, Campbell S, Hallett M, Mills GB, Park M, Chodosh L, Strathdee D, Norman JC, Muller WJ.
Cancer Res. 2016 Mar 1. pii: canres.2782.2015. [Epub ahead of print]
PMID: 26933086

February

CELL GROWTH. (TORC)ing up purine biosynthesis.
Ma EH, Jones RG.
Science. 2016 Feb 12;351(6274):670-1. doi: 10.1126/science.aaf1929. No abstract available.
PMID: 26912848

A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.
Stewart K, Gaitan Y, Shafer ME, Aoudjit L, Hu D, Sharma R, Tremblay M, Ishii H, Marcotte M, Stanga D, Tang YC, Boualia SK, Nguyen AH, Takano T, Lamarche-Vane N, Vidal S, Bouchard M.
PLoS Genet. 2016 Feb 9;12(2):e1005785. doi: 10.1371/journal.pgen.1005785. eCollection 2016 Feb.
PMID: 26859289 Free PMC Article

January

TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies.
Pike KA, Tremblay ML.
Cytokine. 2016 Jan 23. pii: S1043-4666(15)30138-1. doi: 10.1016/j.cyto.2015.12.025. [Epub ahead of print]
PMID: 26817397

Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Belle JI, Petrov JC, Langlais D, Robert F, Cencic R, Shen S, Pelletier J, Gros P, Nijnik A.
Cell Death Differ. 2016 Jan 15. doi: 10.1038/cdd.2015.140. [Epub ahead of print]
PMID: 26768662

Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR 4th, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC.
Nat Med. 2016 Jan 18. doi: 10.1038/nm.4032. [Epub ahead of print]
PMID: 26779812

December

Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer.
Creedon H, Balderstone LA, Muir M, Balla J, Gomez-Cuadrado L, Tracey N, Loane J, Klinowska T, Muller WJ, Brunton VG.
Dis Model Mech. 2015 Dec 31. pii: dmm.023143. [Epub ahead of print]
PMID: 26721874 Free Article

Stat3 establishes an immunosuppressive microenvironment during the early stages of breast carcinogenesis to promote tumor growth and metastasis. Jones LM, Broz ML, Ranger JJ, Ozcelik J, Ahn R, Zuo D, Ursini-Siegel J, Hallett M, Krummel M, Muller WJ.
Cancer Res. 2015 Dec 30. pii: canres.2770.2015. [Epub ahead of print]
PMID: 26719528

Central, But Not Peripheral, Circulating Tumor Cells are Prognostic in Patients Undergoing Resection of Colorectal Cancer Liver Metastases.
Connor AA, McNamara K, Al-Sukhni E, Diskin J, Chan D, Ash C, Lowes LE, Allan AL, Zogopoulos G, Moulton CA, Gallinger S.
Ann Surg Oncol. 2015 Dec 29. [Epub ahead of print]
PMID: 26714949

Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.
Li J, Davidson D, Martins Souza C, Zhong MC, Wu N, Park M, Muller WJ, Veillette A.
Mol Cell Biol. 2015 Dec 1;35(23):4069-82. doi: 10.1128/MCB.00741-15. Epub 2015 Sep 21.
PMID: 26391955

November

The influence of the pre-metastatic niche on breast cancer metastasis.
Ursini-Siegel J, Siegel PM.
Cancer Lett. 2015 Nov 11. pii: S0304-3835(15)00683-7. doi: 10.1016/j.canlet.2015.11.009. [Epub ahead of print]
PMID: 26577808

Colitis-associated colon cancer: Is it in your genes?
Van Der Kraak L, Gros P, Beauchemin N.
World J Gastroenterol. 2015 Nov 7;21(41):11688-99. doi: 10.3748/wjg.v21.i41.11688. Review.
PMID: 26556996 Free PMC Article

Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer.
Smith AL, Alirezaie N, Connor A, Chan-Seng-Yue M, Grant R, Selander I, Bascuñana C, Borgida A, Hall A, Whelan T, Holter S, McPherson T, Cleary S, Petersen GM, Omeroglu A, Saloustros E, McPherson J, Stein LD, Foulkes WD, Majewski J, Gallinger S, Zogopoulos G.
Cancer Lett. 2015 Nov 3. pii: S0304-3835(15)00661-8. doi: 10.1016/j.canlet.2015.10.030. [Epub ahead of print]
PMID: 26546047

October

Signalling to eIF4E in cancer.
Siddiqui N, Sonenberg N.
Biochem Soc Trans. 2015 Oct 1;43(5):763-72. doi: 10.1042/BST20150126. Review.
PMID: 26517881 Free PMC Article

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.
Ramiscal RR, Parish IA, Lee-Young RS, Babon JJ, Blagih J, Pratama A, Martin J, Hawley N, Cappello JY, Nieto PF, Ellyard J, Kershaw NJ, Sweet RA, Goodnow CC, Jones RG, Febbraio MA, Vinuesa C, Athanasopoulos V.
Elife. 2015 Oct 23;4. pii: e08698. doi: 10.7554/eLife.08698. [Epub ahead of print]
PMID: 26496200 Free Article

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Vincent EE, Sergushichev A, Griss T, Gingras MC, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi TC, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, Avizonis D, Pause A, Elder DJ, Artyomov MN, Jones RG.
Mol Cell. 2015 Oct 15;60(2):195-207. doi: 10.1016/j.molcel.2015.08.013.
PMID: 26474064

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration.
Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A.
Cell Rep. 2015 Oct 20;13(3):599-609. doi: 10.1016/j.celrep.2015.09.024. Epub 2015 Oct 8.
PMID: 26456826 Free Article

September

Pax genes in renal development, disease and regeneration.
Sharma R, Sanchez-Ferras O, Bouchard M.
Semin Cell Dev Biol. 2015 Sep 26. pii: S1084-9521(15)00176-7. doi: 10.1016/j.semcdb.2015.09.016. [Epub ahead of print] Review.
PMID: 26410163

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.
Dupaul-Chicoine J, Arabzadeh A, Dagenais M, Douglas T, Champagne C, Morizot A, Rodrigue-Gervais IG, Breton V, Colpitts SL, Beauchemin N, Saleh M.
Immunity. 2015 Sep 14. pii: S1074-7613(15)00345-3. doi: 10.1016/j.immuni.2015.08.013. [Epub ahead of print]
PMID: 26384545

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer.
Dupuy F, Tabariès S, Andrzejewski S, Dong Z, Blagih J, Annis MG, Omeroglu A, Gao D, Leung S, Amir E, Clemons M, Aguilar-Mahecha A, Basik M, Vincent EE, St-Pierre J, Jones RG, Siegel PM.
Cell Metab. 2015 Sep 9. pii: S1550-4131(15)00398-8. doi: 10.1016/j.cmet.2015.08.007. [Epub ahead of print]
PMID: 26365179

August

Atypical Protein Kinase C Induces Cell Transformation by Disrupting Hippo/Yap Signaling.
Archibald A, Al-Masri M, Liew-Spilger A, McCaffrey L.
Mol Biol Cell. 2015 Aug 12. pii: mbc.E15-05-0265. [Epub ahead of print]
PMID: 26269582

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.
Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N.
J Neurosci. 2015 Aug 5;35(31):11125-32. doi: 10.1523/JNEUROSCI.4615-14.2015.
PMID: 26245973

Yap and Taz are required for Ret-dependent urinary tract morphogenesis.
Reginensi A, Hoshi M, Boualia SK, Bouchard M, Jain S, McNeill H.
Development. 2015 Aug 1;142(15):2696-703. doi: 10.1242/dev.122044.
PMID: 26243870

July

Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells.
Zagani R, El-Assaad W, Gamache I, Teodoro JG.
Oncotarget. 2015 Jul 31. [Epub ahead of print]
PMID: 26318046 Free Article

Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.
Bunin A, Sisirak V, Ghosh HS, Grajkowska LT, Hou ZE, Miron M, Yang C, Ceribelli M, Uetani N, Chaperot L, Plumas J, Hendriks W, Tremblay ML, Häcker H, Staudt LM, Green PH, Bhagat G, Reizis B.
Immunity. 2015 Jul 28. pii: S1074-7613(15)00276-9. doi: 10.1016/j.immuni.2015.07.009. [Epub ahead of print]
PMID: 26231120

On the availability of microRNA-induced silencing complexes, saturation of microRNA-binding sites and stoichiometry.
Mayya VK, Duchaine TF.
Nucleic Acids Res. 2015 Jul 30. pii: gkv720. [Epub ahead of print]
PMID: 26227970   Free Article


Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.
Haftchenary S, Jouk AO, Aubry I, Lewis AM, Landry M, Ball DP, Shouksmith AE, Collins CV, Tremblay ML, Gunning PT.
ACS Med Chem Lett. 2015 Jul 22;6(9):982-6. doi: 10.1021/acsmedchemlett.5b00171. eCollection 2015 Sep 10.
PMID: 26396684

There and back again: The journey of the estrogen-related receptors in the cancer realm.
Tam IS, Giguère V.
J Steroid Biochem Mol Biol. 2015 Jul 4. pii: S0960-0760(15)30013-3. doi: 10.1016/j.jsbmb.2015.06.009. [Epub ahead of print]
PMID: 26151739

June

Peroxiredoxin 4: A novel secreted mediator of cancer induced osteoclastogenesis.
Rafiei S, Tiedemann K, Tabariès S, Siegel PM, Komarova SV.
Cancer Lett. 2015 Jun 1;361(2):262-70. doi: 10.1016/j.canlet.2015.03.012. Epub 2015 Mar 14.
PMID: 25779674

May

Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility.
Li R, Knight JF, Park M, Pendergast AM.
PLoS One. 2015 May 6;10(5):e0124960. doi: 10.1371/journal.pone.0124960. eCollection 2015.
PMID: 25946048 Free Article

April

Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.
Martínez A, Sesé M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramón Y Cajal S.
PLoS One. 2015 Apr 29;10(4):e0123352. doi: 10.1371/journal.pone.0123352. eCollection 2015.
PMID: 25923732 Free PMC Article

Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N.
Nat Neurosci. 2015 Apr 27. doi: 10.1038/nn.4010. [Epub ahead of print]
PMID: 25915475

Establishing a clinic-based pancreatic cancer and periampullary tumour research registry in Quebec.
Smith AL, Bascuñana C, Hall A, Salman A, Andrei AZ, Volenik A, Rothenmund H, Ferland D, Lamoussenery D, Kamath AS, Amre R, Caglar D, Gao ZH, Haegert DG, Kanber Y, Michel RP, Omeroglu-Altinel G, Asselah J, Bouganim N, Kavan P, Arena G, Barkun J, Chaudhury P, Gallinger S, Foulkes WD, Omeroglu A, Metrakos P, Zogopoulos G.
Curr Oncol. 2015 Apr;22(2):113-21. doi: 10.3747/co.22.2300.
PMID: 25908910   Free PMC Article

Intratumoral gold-doxorubicin is effective in treating melanoma in mice.
Zhang X, Teodoro JG, Nadeau JL.
Nanomedicine. 2015 Apr 15. pii: S1549-9634(15)00088-X. doi: 10.1016/j.nano.2015.04.001. [Epub ahead of print]
PMID: 25888279

Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673.
Andrei AZ, Hall A, Smith AL, Bascunana C, Malina A, Connor A, Altinel-Omeroglu G, Huang S, Pelletier J, Huntsman D, Gallinger S, Omeroglu A, Metrakos P, Zogopoulos G.
Cancer Lett. 2015 Apr 9. pii: S0304-3835(15)00261-X. doi: 10.1016/j.canlet.2015.04.003. [Epub ahead of print]
PMID: 25864590

G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C.
J Cell Biol. 2015 Apr 13;209(1):73-84. doi: 10.1083/jcb.201408092. Epub 2015 Apr 6.
PMID: 25847539

Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis.
Tabariès S, Annis MG, Hsu BE, Tam CE, Savage P, Park M, Siegel PM.
Oncotarget. 2015 Apr 20;6(11):9476-87.
PMID: 25823815 Free Article

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.
Liberman N, Gandin V, Svitkin YV, David M, Virgili G, Jaramillo M, Holcik M, Nagar B, Kimchi A, Sonenberg N.
Nucleic Acids Res. 2015 Apr 20;43(7):3764-75. doi: 10.1093/nar/gkv205. Epub 2015 Mar 16.
PMID: 25779044  Free PMC Article


A Drosophila-centric view of protein tyrosine phosphatases.
Hatzihristidis T, Desai N, Hutchins AP, Meng TC, Tremblay ML, Miranda-Saavedra D.
FEBS Lett. 2015 Apr 13;589(9):951-966. doi: 10.1016/j.febslet.2015.03.005. Epub 2015 Mar 13. Review.
PMID: 25771859

Targeting the translation machinery in cancer.
Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J, Topisirovic I.
Nat Rev Drug Discov. 2015 Apr;14(4):261-78. doi: 10.1038/nrd4505. Epub 2015 Mar 6.
PMID: 25743081

p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency.
Belle JI, Langlais D, Petrov JC, Pardo M, Jones RG, Gros P, Nijnik A.
Blood. 2015 Apr 9;125(15):2344-8. doi: 10.1182/blood-2014-05-574111. Epub 2015 Feb 20.
PMID: 25710881

March

Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases.
Tabariès S, Ouellet V, Hsu BE, Annis MG, Rose AA, Meunier L, Carmona E, Tam CE, Mes-Masson AM, Siegel PM.
Breast Cancer Res. 2015 Mar 27;17(1):45. doi: 10.1186/s13058-015-0558-3.
PMID: 25882816 Free PMC Article

GPNMB cooperates with neuropilin-1 to promote mammary tumor growth and engages integrin for efficient breast cancer metastasis.
Maric G, Annis MG, Dong Z, Rose AA, Ng S, Perkins D, MacDonald PA, Ouellet V, Russo C, Siegel PM.
Oncogene. 2015 Mar 16. doi: 10.1038/onc.2015.8. [Epub ahead of print]
PMID: 25772243

Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection.
Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Tamarkin-Ben-Harush A, Viollet B, Dikstein R.
Cell Metab. 2015 Mar 3;21(3):479-92. doi: 10.1016/j.cmet.2015.02.010.
PMID: 25738462

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.
Ioannou MS, Bell ES, Girard M, Chaineau M, Hamlin JN, Daubaras M, Monast A, Park M, Hodgson L, McPherson PS.
J Cell Biol. 2015 Mar 2;208(5):629-48. doi: 10.1083/jcb.201407068. Epub 2015 Feb 23.
PMID: 25713415

February

 

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS.
Nat Commun. 2015 Feb 18;6:6217. doi: 10.1038/ncomms7217.
PMID: 25692415 [PubMed - as supplied by publisher]
   
The IGF-trap: novel inhibitor of carcinoma growth and metastasis.
Wang N, Rayes RF, Elahi SM, Lu Y, Hancock MA, Massie B, Rowe GE, Aomari H, Hossain S, Durocher Y, Pinard M, Tabariès S, Siegel PM, Brodt P.
Mol Cancer Ther. 2015 Feb 11. pii: molcanther.0751.2014. [Epub ahead of print]
PMID: 25673819  [PubMed - as supplied by publisher]
   
Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells.
Arabzadeh A, Dupaul-Chicoine J, Breton V, Haftchenary S, Yumeen S, Turbide C, Saleh M, McGregor K, Greenwood CM, Akavia UD, Blumberg RS, Gunning PT, Beauchemin N.
Gut. 2015 Feb 9. pii: gutjnl-2014-308781. doi: 10.1136/gutjnl-2014-308781. [Epub ahead of print]
PMID: 25666195  [PubMed - as supplied by publisher]
   
SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lungcancer.
Papadakis AI, Sun C, Knijnenburg TA, Xue Y, Grernrum W, Hölzel M, Nijkamp W, Wessels LF, Beijersbergen RL, Bernards R, Huang S.
Cell Res. 2015 Feb 6. doi: 10.1038/cr.2015.16. [Epub ahead of print]
PMID: 25656847
   
Analysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.
Sriskandarajah N, Blanchette P, Kucharski TJ, Teodoro J, Branton PE.
J Virol. 2015 Feb 4. pii: JVI.03437-14. [Epub ahead of print]
PMID: 25653433

 

 

January

Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion and metastasis.
Pettersson F, Del Rincon SV, Emond A, Huor B, Ngan E, Ng J, Dobocan MC, Siegel PM, Miller WH Jr.
Cancer Res. 2015 Jan 21. pii: canres.1996.2014. [Epub ahead of print]
PMID:25608710  [PubMed - as supplied by publisher]

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo.
Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJ, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG.
Immunity. 2015 Jan 20;42(1):41-54. doi: 10.1016/j.immuni.2014.12.030. Epub 2015 Jan 2.
PMID: 25607458

mTOR coordinates protein synthesis, mitochondrial activity and proliferation.
Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, Topisirovic I.
Cell Cycle. 2015 Jan 15:0. [Epub ahead of print]
PMID: 25590164
  
The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.
Ramdzan ZM, Pal R, Kaur S, Leduy L, Bérubé G, Davoudi S, Vadnais C, Nepveu A.
Oncotarget. 2015 Jan 8. [Epub ahead of print]
PMID: 25682875 [PubMed - as supplied by publisher] Free Article

December

Developmental differences in the expression of FGF receptors between human and mouse embryos.
Kunath T, Yamanaka Y, Detmar J, MacPhee D, Caniggia I, Rossant J, Jurisicova A.
Placenta. 2014 Dec;35(12):1079-88. doi: 10.1016/j.placenta.2014.09.008. Epub 2014 Sep 23.
PMID: 25443433 [PubMed - in process]

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.
Bah A, Vernon RM, Siddiqui Z, Krzeminski M, Muhandiram R, Zhao C, Sonenberg N, Kay LE, Forman-Kay JD.
Nature. 2014 Dec 22. doi: 10.1038/nature13999. [Epub ahead of print]
PMID: 25533957

Absolute assignment of breast cancer intrinsic molecular subtype.
Paquet ER, Hallett MT.
J Natl Cancer Inst. 2014 Dec 4;107(1):357. doi: 10.1093/jnci/dju357. Print 2015 Jan.
PMID: 25479802

Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Foveau B, Van Der Kraak L, Beauchemin N, Albrecht S, LeBlanc AC.
PLoS One. 2014 Dec 3;9(12):e114270. doi: 10.1371/journal.pone.0114270. eCollection 2014.
PMID: 25470254 [PubMed - in process] Free PMC Article
   
Chemoprevention Activity of 25-Hydroxyvitamin D in the MMTV-PyMT Mouse Model of BreastCancer.
Rossdeutscher L, Li J, Luco AL, Fadhil I, Ochietti B, Camirand A, Huang DC, Reinhardt TA, Muller W, Kremer R.
Cancer Prev Res (Phila). 2015 Feb;8(2):120-8. doi: 10.1158/1940-6207.CAPR-14-0110. Epub 2014 Dec 2.
PMID:
25468832

November

Phase I/II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Patients With Locally Advanced or Metastatic Breast Cancer.
Bendell J, Saleh M, Rose AA, Siegel PM, Hart L, Sirpal S, Jones S, Green J, Crowley E, Simantov R, Keler T, Davis T, Vahdat L.
J Clin Oncol. 2014 Nov 10;32(32):3619-25. doi: 10.1200/JCO.2013.52.5683. Epub 2014 Sep 29.
 
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice.
El-Assaad W, El-Kouhen K, Mohammad AH, Yang J, Morita M, Gamache I, Mamer O, Avizonis D, Hermance N, Kersten S, Tremblay ML, Kelliher MA, Teodoro JG.
Diabetologia. 2014 Nov 9. [Epub ahead of print]

Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.
Liu X, Giguère V.
Nucl Recept Signal. 2014 Nov 4;12:e004. doi: 10.1621/nrs.12004. eCollection 2014.
PMID: 25422594 [PubMed - in process] Free PMC Article

October

Estrogen-Related Receptor Alpha coordinates transcriptional programs essential for exercise tolerance and muscle fitness.
Perry MC, Dufour CR, Tam IS, B'chir W, Giguère V.
Mol Endocrinol. 2014 Oct 31:me20141281. [Epub ahead of print]
PMID: 25361393

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.
Nature. 2014 Oct 26. doi: 10.1038/nature13848.

MS/MS-based strategies for proteomic profiling of invasive cell structures.
Havrylov S, Park M.
Proteomics. 2014 Oct 10. doi: 10.1002/pmic.201400220. [Epub ahead of print]
PMID: 25303514

The prognostic ease and difficulty of invasive breast carcinoma.
Tofigh A, Suderman M, Paquet ER, Livingstone J, Bertos N, Saleh SM, Zhao H, Souleimanova M, Cory S, Lesurf R, Shahalizadeh S, Garcia Lopez N, Riazalhosseini Y, Omeroglu A, Ursini-Siegel J, Park M., Dumeaux V, Hallett M.
Cell Rep. 2014 Oct 9;9(1):129-42. doi: 10.1016/j.celrep.2014.08.073. Epub 2014 Oct 2.
PMID: 25284793 [PubMed - in process] Free Article

MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.
Fukao A, Mishima Y, Takizawa N, Oka S, Imataka H, Pelletier J, Sonenberg N, Thoma C, Fujiwara T.
Mol Cell. 2014 Oct 2;56(1):79-89. doi: 10.1016/j.molcel.2014.09.005.
PMID: 25280105 [PubMed - in process]

September

The ever-evolving role of mTOR in translation.
Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A.
Semin Cell Dev Biol. 2014 Sep 26. pii: S1084-9521(14)00269-9. doi: 10.1016/j.semcdb.2014.09.014. [Epub ahead of print] Review.
PMID: 25263010
           
ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.
Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V.
Mol Cell Biol. 2014 Sep 22. pii: MCB.00895-14. [Epub ahead of print]
PMID: 25246633
     
Differential effects of AMPK agonists on cell growth and metabolism.
Vincent EE, Coelho PP, Blagih J, Griss T, Viollet B, Jones RG.
Oncogene. 2014 Sep 22. doi: 10.1038/onc.2014.301. [Epub ahead of print]
PMID: 25241895

Coordinated cell behaviours in early urogenital system morphogenesis.
Stewart K, Bouchard M.
Semin Cell Dev Biol. 2014 Sep 16. pii: S1084-9521(14)00256-0. doi: 10.1016/j.semcdb.2014.09.001. [Epub ahead of print] Review.
PMID: 25220017

Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers.
Vadnais C, Shooshtarizadeh P, Rajadurai CV, Lesurf R, Hulea L, Davoudi S, Cadieux C, Hallett M, Park M, Nepveu A.
Biol Open. 2014 Sep 12. pii: BIO20148193. doi: 10.1242/bio.20148193. [Epub ahead of print]
PMID: 25217618

Distinctive tRNA Repertoires in Proliferating versus Differentiating Cells.
Topisirovic I, Sonenberg N.
Cell. 2014 Sep 11;158(6):1238-9. doi: 10.1016/j.cell.2014.08.031.
PMID: 25215483

Interaction of Adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.
Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG.
J Virol. 2014 Sep 10. pii: JVI.00933-14. [Epub ahead of print]
PMID: 25210169

A regulatory network controls nephrocan expression and midgut patterning.
Hou J, Wei W, Saund RS, Xiang P, Cunningham TJ, Yi Y, Alder O, Lu DY, Savory JG, Krentz NA, Montpetit R, Cullum R, Hofs N, Lohnes D, Humphries RK, Yamanaka Y, Duester G, Saijoh Y, Hoodless PA.
Development. 2014 Sep 10. pii: dev.108274. [Epub ahead of print]
PMID: 25209250

CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.
Ramdzan ZM, Nepveu A.
Nat Rev Cancer. 2014 Sep 5. doi: 10.1038/nrc3805. [Epub ahead of print]
PMID: 25190083

DICER1: mutations, microRNAs and mechanisms.
Foulkes WD, Priest JR, Duchaine TF.
Nat Rev Cancer. 2014 Sep 1. doi: 10.1038/nrc3802. [Epub ahead of print]
PMID: 25176334

August

Metformin directly acts on mitochondria to alter cellular bioenergetics.
Andrzejewski S, Gravel SP, Pollak M, St-Pierre J.
Cancer Metab. 2014 Aug 28;2:12. doi: 10.1186/2049-3002-2-12. eCollection 2014.
PMID: 25184038
     
Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancercells is mediated by PARP activation and enhanced NAD consumption.
Chan M, Gravel M, Bramoulle A, Bridon G, Avizonis D, Shore GC, Roulston A.
Cancer Res. 2014 Aug 21. pii: canres.0809.2014. [Epub ahead of print]
PMID: 25145669
       
Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.
Bagci H, Laurin M, Huber J, Muller WJ, Côté JF.
Cell Death Dis. 2014 Aug 14;5:e1375. doi: 10.1038/cddis.2014.338.
PMID: 25118935

Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3.
Archibald A, Mihai C, Macara IG, McCaffrey L.
Oncogene. 2014 Aug 11;0. doi: 10.1038/onc.2014.242. [Epub ahead of print]
PMID: 25109337

July

Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo.
Anani S, Bhat S, Honma-Yamanaka N, Krawchuk D, Yamanaka Y.
Development. 2014 Jul;141(14):2813-24. doi: 10.1242/dev.107276. Epub 2014 Jun 19.
PMID: 24948601
       
Circulation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts.
Tanaka Y, Sanchez V, Takata N, Yokomizo T, Yamanaka Y, Kataoka H, Hoppe PS, Schroeder T, Nishikawa S.
Cell Rep. 2014 Jul 10;8(1):31-9. doi: 10.1016/j.celrep.2014.05.055. Epub 2014 Jun 26.
PMID: 24981862 [PubMed - in process]
       
Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.
Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N.
RNA. 2014 Jul 17. [Epub ahead of print]
PMID: 25035296 [PubMed - as supplied by publisher]
        
APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly.
Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG.
Cell. 2014 Jul 17;158(2):368-82. doi: 10.1016/j.cell.2014.05.042.
PMID: 25036633

 p66ShcA Promotes Breast Cancer Plasticity by Inducing an Epithelial to Mesenchymal Transition.
Hudson J, Ha JR, Sabourin V, Ahn R, La Selva R, Livingstone J, Podmore L, Knight J, Forrest L, Beauchemin N, Hallett M, Park M, Ursini-Siegel J.
Mol Cell Biol. 2014 Jul 28. pii: MCB.00341-14. [Epub ahead of print]

June

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
Ming Yan, Marie-Claude Gingras, Elaine A. Dunlop, Yann Nouët, Fanny Dupuy, Zahra Jalali, Elite Possik, Barry J. Coull, Dmitri Kharitidi, Anders Bondo Dydensborg, Brandon Faubert, Miriam Kamps, Sylvie Sabourin, Rachael S. Preston, David Mark Davies, Taren Roughead, Laëtitia Chotard, Maurice A.M. van Steensel, Russell Jones, Andrew R. Tee, Arnim Pause
J Clin Invest. 2014 June 2; 124(6): 2640–2650. Published online 2014 April 24. doi: 10.1172/JCI71749
PMCID: PMC4038567
       
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.
Robichaud N, Del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N.
Oncogene. 2014 Jun 9. doi: 10.1038/onc.2014.146. [Epub ahead of print]
PMID: 24909168
       
Translational control of immune responses: from transcripts to translatomes.
Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N, Larsson O.
Nat Immunol. 2014 Jun;15(6):503-11. doi: 10.1038/ni.2891. Review.
PMID: 24840981

May

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.
Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J.
Oncogene. 2014 May 19. doi: 10.1038/onc.2014.110. [Epub ahead of print]
PMID: 24837366
       
Amino acids fuel T cell-mediated inflammation.
Poffenberger MC, Jones RG.
Immunity. 2014 May 15;40(5):635-7. doi: 10.1016/j.immuni.2014.04.017.
PMID: 24837098

YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway.
Zhao Y, Khanal P, Savage P, She YM, Cyr TD, Yang X.
Cancer Res. 2014 May 8. [Epub ahead of print]
PMID: 24812269

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.
Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset PO, Bechet D, Faury D, De Jay N, Ramkissoon LA, Corcoran A, Jones DT, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers DC, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Leary S, Jallo G, Cohen K, Gupta N, Prados MD, Carret AS, Ellezam B, Crevier L, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Dong Z, Siegel PM, Malkin H, Ligon AH, Albrecht S, Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW.
Nat Genet. 2014 May;46(5):462-6. doi: 10.1038/ng.2950. Epub 2014 Apr 6.
PMID: 24705250

April

Stable isotope tracer analysis in isolated mitochondria from Mammalian systems.
Gravel SP, Andrzejewski S, Avizonis D, St-Pierre J.
Metabolites. 2014 Apr 10;4(2):166-83. doi: 10.3390/metabo4020166.
PMID: 24957021 [PubMed]
       
Gene regulatory network of renal primordium development.
Marcotte M, Sharma R, Bouchard M.
Pediatr Nephrol. 2014 Apr;29(4):637-44. doi: 10.1007/s00467-013-2635-0. Epub 2013 Oct 9.
PMID: 24104595

March

It takes two to tango in the microenvironment!
Ursini-Siegel J, Park M. Breast Cancer Res. 2013 Mar 12;15(2):102. [Epub ahead of print] PMID: 23510134 [PubMed - as supplied by publisher]

Gata3 antagonizes cancer progression in Pten-deficient prostates.
Nguyen AH, Tremblay M, Haigh K, Koumakpayi IH, Paquet M, Pandolfi PP, Mes-Masson AM, Saad F, Haigh JJ, Bouchard M. Hum Mol Genet. 2013 Mar 6. [Epub ahead of print] PMID: 23428429 [PubMed - as supplied by publisher]
        
Remote control of gene function by local translation.
Jung H, Gkogkas CG, Sonenberg N, Holt CE.
Cell. 2014 Mar 27;157(1):26-40. doi: 10.1016/j.cell.2014.03.005. Review.
PMID: 24679524
       
Rewiring cell polarity signaling in cancer.
Halaoui R, McCaffrey L.
Oncogene. 2014 Mar 17. doi: 10.1038/onc.2014.59. [Epub ahead of print]
PMID: 24632617
       
The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.
Hardy S, Uetani N, Wong N, Kostantin E, Labbé DP, Bégin LR, Mes-Masson A, Miranda-Saavedra D, Tremblay ML.
Oncogene. 2014 Mar 17. doi: 10.1038/onc.2014.33. [Epub ahead of print]
PMID: 24632616

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.
Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N.
Mol Cell Biol. 2014 Mar;34(6):1046-53. doi: 10.1128/MCB.01079-13. Epub 2014 Jan 6.
PMID: 24396066

February

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.
Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG.
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2554-9. doi: 10.1073/pnas.1312570111. Epub 2014 Feb 3.
PMID: 24550282
       
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.
Labbé DP, Nowak DG, Deblois G, Lessard L, Giguère V, Trotman LC, Tremblay ML.
Mol Cancer Res. 2014 Feb;12(2):184-9. doi: 10.1158/1541-7786.MCR-13-0477. Epub 2013 Dec 30.
PMID: 24379448

January

Translational control and autism-like behaviors.
Gkogkas CG, Sonenberg N.
Cell Logist. 2013 Jan 1;3(1):e24551. Epub 2013 Apr 4.
PMID: 24516777 [PubMed]
       
The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator.
Faubert B, Vincent EE, Poffenberger MC, Jones RG.
Cancer Lett. 2014 Jan 28. pii: S0304-3835(14)00054-8. doi: 10.1016/j.canlet.2014.01.018. [Epub ahead of print]
PMID: 24486219
       
Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR.
Kleinman CL, Gerges N, Papillon-Cavanagh S, Sin-Chan P, Pramatarova A, Quang DA, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Fontebasso AM, Spence T, Schwartzentruber J, Albrecht S, Hauser P, Garami M, Klekner A, Bognar L, Montes JL, Staffa A, Montpetit A, Berube P, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel PM, Duchaine T, Perotti C, Fleming A, Faury D, Remke M, Gallo M, Dirks P, Taylor MD, Sladek R, Pastinen T, Chan JA, Huang A, Majewski J, Jabado N.
Nat Genet. 2014 Jan;46(1):39-44. doi: 10.1038/ng.2849. Epub 2013 Dec 8.
PMID: 24316981
       
Parallel measurement of dynamic changes in translation rates in single cells.
Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T.
Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10.
PMID: 24213167

Pseudophosphatases: methods of analysis and physiological functions.
Kharitidi D, Manteghi S, Pause A.
Methods. 2014 Jan 15;65(2):207-18. doi: 10.1016/j.ymeth.2013.09.009. Epub 2013 Sep 21.
PMID: 24064037

December

Arsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer.
Guilbert C, Annis MG, Dong Z, Siegel PM, Miller WH Jr, Mann KK.
PLoS One. 2013 Dec 31;8(12):e85995. doi: 10.1371/journal.pone.0085995. eCollection 2013.
PMID:24392034

Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues.
Axford MM, Wang YH, Nakamori M, Zannis-Hadjopoulos M, Thornton CA, Pearson CE.
PLoS Genet. 2013 Dec;9(12):e1003866. doi: 10.1371/journal.pgen.1003866. Epub 2013 Dec 19
PMID: 24367268

PGC-1α supports glutamine metabolism in breast cancer.
McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J.
Cancer Metab. 2013 Dec 5;1(1):22. doi: 10.1186/2049-3002-1-22.
PMID: 24304688

FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst.
Krawchuk D, Honma-Yamanaka N, Anani S, Yamanaka Y.
Dev Biol. 2013 Dec 1;384(1):65-71. doi: doi: 10.1016/j.ydbio.2013.09.023. Epub 2013 Sep 21.
PMID: 24063807

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis.
Beauchemin N, Arabzadeh A.
Cancer Metastasis Rev. 2013 Dec;32(3-4):643-71. doi: 10.1007/s10555-013-9444-6.
PMID: 23903773 

November

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N.
Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001.
PMID: 24206664

October

Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.
Hong EJ, Levasseur MP, Dufour CR, Perry MC, Giguère V.
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17975-80. doi: 10.1073/pnas.1315319110. Epub 2013 Oct 14.
PMID: 24127579
       
A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis.
Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M.
Dev Biol. 2013 Oct 15;382(2):555-66. doi: 10.1016/j.ydbio.2013.07.028. Epub 2013 Aug 3.
PMID: 23920117

September

Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
Ayoub E, Hall A, Scott AM, Chagnon MJ, Miquel G, Hallé M, Noda M, Bikfalvi A, Tremblay ML.
J Biol Chem. 2013 Sep 6;288(36):25739-48. doi: 10.1074/jbc.M113.501007. Epub 2013 Jul 29.
PMID:23897807

August

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.
Dupuy F, Griss T, Blagih J, Bridon G, Avizonis D, Ling C, Dong Z, Siwak DR, Annis MG, Mills GB, Muller WJ, Siegel PM, Jones RG.
Cancer Metab. 2013 Aug 14;1(1):18. doi: 10.1186/2049-3002-1-18.
PMID: 24280377
       
A truncated form of dicer tilts the balance of RNA interference pathways.

Sawh AN, Duchaine TF.
Cell Rep. 2013 Aug 15;4(3):454-63. doi: 10.1016/j.celrep.2013.07.013. Epub 2013 Aug 8.
PMID: 23933256 
       
Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.
Stewart K, Uetani N, Hendriks W, Tremblay ML, Bouchard M.
Development. 2013 Aug;140(16):3413-22. doi: 10.1242/dev.094532. Epub 2013 Jul 17.
PMID: 23863482

July

Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer.
Maric G, Rose AA, Annis MG, Siegel PM.
Onco Targets Ther. 2013 Jul 9;6:839-52. doi: 10.2147/OTT.S44906. Print 2013.
PMID: 23874106 [PubMed]

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.
Ahn R, Sabourin V, Ha JR, Cory S, Maric G, Im YK, Hardy WR, Zhao H, Park M, Hallett M, Siegel PM, Pawson T, Ursini-Siegel J.
Cancer Res. 2013 Jul 15;73(14):4521-32. doi: 10.1158/0008-5472.CAN-12-4178. Epub 2013 May 21.
PMID: 23695548

June

Gata3 antagonizes cancer progression in Pten-deficient prostates.
Nguyen AH, Tremblay M, Haigh K, Koumakpayi IH, Paquet M, Pandolfi PP, Mes-Masson AM, Saad F, Haigh JJ, Bouchard M.
Hum Mol Genet. 2013 Jun 15;22(12):2400-10. doi: 10.1093/hmg/ddt088. Epub 2013 Feb 20.
PMID: 23428429

May

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.
Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N.
PLoS Biol. 2013;11(5):e1001564. doi: 10.1371/journal.pbio.1001564. Epub 2013 May 21.
PMID: 23700384
       

A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.
Ngan E, Northey JJ, Brown CM, Ursini-Siegel J, Siegel PM.
J Cell Sci. 2013 May 1;126(Pt 9):1981-91. doi: 10.1242/jcs.118315. Epub 2013 Feb 27.
PMID: 23447672

April

Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.
Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R, Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N.
Neuron. 2013 Apr 24;78(2):298-311. doi: 10.1016/j.neuron.2013.02.025.
PMID: 23622065
       
Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver.
Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V.
Cell Metab. 2013 Apr 2;17(4):586-98. doi: 10.1016/j.cmet.2013.03.003.
PMID: 23562079
       
Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer.

Knight JF, Lesurf R, Zhao H, Pinnaduwage D, Davis RR, Saleh SM, Zuo D, Naujokas MA, Chughtai N, Herschkowitz JI, Prat A, Mulligan AM, Muller WJ, Cardiff RD, Gregg JP, Andrulis IL, Hallett MT, Park M.
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1301-10. doi: 10.1073/pnas.1210353110. Epub 2013 Mar 18.
PMID: 23509284

The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring GC/MS.
Mamer O, Gravel SP, Choinière L, Chénard V, St-Pierre J, Avizonis D.
Metabolomics. 2013;9:1019-1030. Epub 2013 Apr 17.
PMID: 24348278

March

 

 

February

ELF3 is a repressor of androgen receptor action in prostate cancer cells.
Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V.
Oncogene. 2014 Feb 13;33(7):862-71. doi: 10.1038/onc.2013.15. Epub 2013 Feb 25.
PMID: 23435425

January

Development: New Wrinkles on Genetic Control of the MBT.
Lasko P.
Curr Biol. 2013 Jan 21;23(2):R65-7. doi: 10.1016/j.cub.2012.12.012.
PMID: 23347940
        
Translational control and autism-like behaviors.
Gkogkas CG, Sonenberg N.
Cell Logist. 2013 Jan 1;3(1):e24551. Epub 2013 Apr 4.
PMID: 24516777 [PubMed]
       
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N.
Nature. 2013 Jan 17;493(7432):371-7. doi: 10.1038/nature11628. Epub 2012 Nov 21. PMID: 23172145 [PubMed - indexed for MEDLINE]
       
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond. Deblois G, Giguère V. Nat Rev Cancer. 2013 Jan;13(1):27-36. doi: 10.1038/nrc3396. Epub 2012 Nov 29. Review. PMID: 23192231 [PubMed - indexed for MEDLINE]