Few universities in the world can match McGill’s achievements in medical research, and nowhere is this more evident than in the field of cancer. In the past few years alone, researchers at the Goodman Cancer Research Centre have made several landmark discoveries. Highlights of these discoveries include:
A research team lead by Morag Park and Michael Hallett has identified various gene profiles that could help to readily identify types of breast cancer. In addition to providing back-up identification to pathologists, this discovery will help oncologists choose the most effective treatment types for individual cases.
Additional discoveries made by GCRC researchers:
• Cloning and characterization of gene coding for transporters involved in the acquisition of multidrug resistance.
• Cloning and characterization of the gene coding for the human tumor marker carcinoembryonic antigen (CEA); discovery and elucidation of tumorigenic properties.
• Demonstration of tumor-suppressing activity of the biliary glycoprotein (BGP).
• Isolation and characterization of mammalian origins of DNA replication.
• Identification of vertebrate Hox proteins as transcriptional activators.
• Characterization of enzymes involved in protein glycosylation.
• Identification of the WT1 tumor suppressor gene product as a transcriptional repressor involved in Wilm's tumor in children.
• Identification and characterization of proteins involved in the positive and negative regulation of T-lymphocyte activation.
• Identification of translational elements as oncogenes; modulating genes implicated in translation machinery and cancer.
• Polycistronic elements in eukaryotic messengers [IRES].
• Identification of novel PTPases in cancer, diabetes, obesity and neuronal regeneration.
• Identification of p53 independent apoptotic inducers.